Volume 7 (2023-2024)
Volume 6 (2022-2023)
Volume 5 (2021-2022)
Volume 4 (2020-2021)
Volume 3 (2019-2020)
Volume 2 (2018-2019)
Volume 1 (2017-2018)
Main Subjects = Biological sciences
Number of Articles: 22
The association of the human papilloma virus genotypes and telomerase gene polymorphisms in cervical lesion
Articles in Press, Accepted Manuscript, Available Online from 07 April 2024
Abstract
A leading risk factor for cervical cancer (CC) initiation and progress includes human papillomavirus (HPV) infection. The telomerase catalytic subunit which regulates senescence and proliferation (carcinogenesis) is encoded by human telomerase reverse transcriptase (hTERT) gene. Our objective was the ... Read MoreElucidating the Probiotic Function of Lactic Acid Bacteria in Aflatoxin Mitigation from Dairy Products
Articles in Press, Accepted Manuscript, Available Online from 14 April 2024
Abstract
Dairy products are susceptible to contamination by various microorganisms, including fungal species, throughout the production, distribution, and storage phases, primarily due to non-compliance with hygienic standards. Notably, fungal microorganisms exhibit resilience to acidic and low-temperature environments, ... Read MoreGC/MS analysis and antifungal activity of M. Chamomilla extracts against molecularly identified keratinophilic fungi
Volume 7, Issue 4 , March 2024, , Pages 24-43
Abstract
The objective of this study was to isolate and genetically identify keratinophilic fungi associated with humans, test their susceptibility to nystatin, and evaluate the effectiveness of Methanol Extract (ME) from chamomile flowers against these fungi. No cytotoxic effects were observed in the extract ... Read MoreParameter changes of COVID-19 incidence in Baghdad/Iraq in 2020: Infected and cured individuals: A retrospective single center study
Volume 7, Issue 4 , March 2024, , Pages 44-62
Abstract
Coronavirus disease 2019 (COVID-19) represented a highly respiratory syndrome to worldwide. Aim of current research was to determine the changes in hematology and inflammatory parameters into three categories: non-infected with COVID-19 as control groups, infected with COVID-19 and cured from the disease ... Read MoreInvestigating the effects of Zataria Multiflora essential oil and silver nanoparticles on the expression of abaI and pil genes in Acinetobacter baumannii biofilm formation
Volume 7, Issue 4 , March 2024, , Pages 63-80
Abstract
The aim of this research was to investigate the effect of Zataria multiflora and silver nanoparticles on the biofilm formation ability of A. baumannii and the expression of genes involved in this process. Thirty isolates of A. baumannii bacteria were collected and studied from the Milad Hospital of Tehran. ... Read MoreBiofilm formation and drug resistance determinants of Moraxella catarrhalis, Moraxella osloensis and Moraxella lacunata from clinical samples in Iraq
Volume 7, Issue 4 , March 2024, , Pages 81-97
Abstract
In this study, fifty Moraxella species were isolated. The antibiotic susceptibility, β-lactamases and minimum inhibitory and bactericidal concentrations were evaluated. The rate of ESBLs among M. catarrhalis, M. osloensis and M. lacunata included 47 % (n=11), 36.84 % (n=7) and 37.5 % (n=3), respectively. ... Read MoreEZH2 expression role in angiogenesis of prostate malignancy
Volume 7, Issue 3 , December 2023, , Pages 10-29
Abstract
The gene Enhancer of Zeste Homolog 2 (EZH2) is shown to be involved in the progression of the angiogenesis in cancer including prostate cancer, also it is a well-known enzyme catalytic subunit, initially acting as a histone methyltransferase, to prevent expressing gene by trimethylating lysine at the ... Read MoreExploring bacillus subtilis isolated from soil as a promising alternative for L-asparaginase enzyme production
Volume 7, Issue 3 , December 2023, , Pages 45-61
Abstract
In this study, eight bacterial isolates were obtained from the 35 soil samples of Golestan province in Iran. Samples were collected from different soils and cultured in an M9 medium. Enzyme-producing colonies were distinguished by the color change from yellow to pink. 16s rRNA sequencing identified L-asparaginase ... Read MoreInvestigating the association between Toll-Like Receptor 9 (TLR9) rs352139 genetic variants and Systemic Lupus Erythematosus (SLE) in an Iranian population
Volume 7, Issue 3 , December 2023, , Pages 77-91
Abstract
Numerous studies have examined the effect of genetic variations in the Toll-Like Receptor 9 (TLR9) on the development of Systemic Lupus Erythematosus (SLE). An allele-specific PCR technique was employed to analyze the genetic variation in the study participants in a cohort of SLE and healthy controls ... Read MoreA review of similarity of KLF2, MSX1 and SOX9 genes expression in zebrafish and human
Volume 7, Issue 2 , September 2023, , Pages 18-34
Abstract
In recent studies, the focus on zebrafish, as a suitable laboratory model for studying vertebrate gene function, has increased dramatically. We evaluated the similarity between the three genes KLF2, MSX1 and SOX9 in humans and zebrafish. The KLF2 gene plays a role in heart and immunity of humans and ... Read MorePreconditioning with IFN-γ and LPS improves the immunomodulatory potential of bone marrow-derived clonal mesenchymal stem cells
Volume 7, Issue 2 , September 2023, , Pages 35-51
Abstract
Mesenchymal Stem Cells (MSCs) are one of the promising cellular therapies for immune-related diseases. Preconditioning of MSCs increases their efficacy and overcomes several hurdles in MSC-based therapies. It reduces tissue inflammation and improves cell survival, consequently enhancing therapeutic outcomes. ... Read MoreGenotyping of KELL blood group in multiethnic populations of Quetta, Pakistan
Volume 7, Issue 2 , September 2023, , Pages 66-81
Abstract
KEL1 (Kell or K) is highly immunogenic with limited distribution while KEL2 (Cellano or k) antigen is more prevalent. The antigenic diversity in the Kell gene is a result of Single Nucleotide Polymorphisms (SNPs). Blood samples of 160 males and females from each ethnic group with no age restrictions ... Read MoreThe golden doses of anti CD3/CD28 microbeads plus IL-15 promote expansion of specific T cells in human cytomegalovirus adaptive immunotherapy
Volume 7, Issue 1 , July 2023, , Pages 22-45
Abstract
In this study, the use of anti-CD3/CD28 magnetic microbeads and IL-15 in the culture of T lymphocytes in vitro had a significant role in the proliferation and cytotoxicity of these cells. Peripheral blood mononuclear cells of 6 (Cytomegalovirus) HCMV positive volunteers were harvested, then the pure ... Read MorePolyherbal formulation: An alternative therapeutic approach to treat diabetic foot ulcer
Volume 6, Issue 4 , March 2023, , Pages 1-13
Abstract
Diabetic Foot Ulcers (DFUs) are a common complication of poorly controlled diabetes and often become infected, termed diabetic foot infection. Despite using several multidisciplinary techniques, no significant cure is still achievable. So, it needs an alternative therapeutic approach to treat diabetic ... Read MoreInduction and evaluation of influenza cell-mediated immune responses by HA2 subunit and bio adjuvant as a gene vaccine candidate
Volume 6, Issue 4 , March 2023, , Pages 56-66
Abstract
The stalk domain of influenza as Hemagglutinin 2 (HA2) is a conserved unit of HA and is a candidate for a vaccine construct. We designed HA2/Mx (Myxovirus Resistance) as bio adjuvant construct for vaccine candidates. After immunization of Razi Balb/c mice in DNA/prime/boost strategy, for determination ... Read MoreWhole exome sequencing reveals the first c.7456C>T p.Arg2486X mutation in ATM gene in Iranian population
Volume 6, Issue 3 , December 2022, , Pages 57-72
Abstract
Mutations in Ataxia-Telangiectasia Mutated (ATM) gene are prominently responsible for the condition. ATM gene encodes a serine/threonine protein kinase, a crucial component in DNA repair systems. Whole exome sequencing was performed on a nine year old male subject with clinical features of A-T. Alpha ... Read MoreEctodermal Dysplasia patients susceptible to COVID-19
Volume 6, Issue 2 , September 2022, , Pages 78-80
Abstract
Ectodermal dysplasia (ED) is a rare heterogeneous disorder. Defects in the development of the ectoderm cause symptoms in tissues derived from the ectoderm layer such as skin, nails and hair. One of the genes involved in ED is Nuclear Factor Kappa-B (NF-κB) that mutation in this gene causes immunodeficiency. ... Read MoreBiotransformation of atropine, 4-hydroxy coumarin, 8-hydroxy quinoline, indole and penicillin G by the natural microflora
Volume 6, Issue 1 , June 2022, , Pages 13-25
Abstract
It has been found that natural microorganism have a siginificant role in the production and development of new medicines. The present study aimed to evaluat biotransformation of atropine, 4-hydroxy coumarin, 8-hydroxy quinoline, indole and industrially compound (penicillin G), arrive in the human body, ... Read MoreThe effect of Ajuga reptans extract on in vitro maturation of rat oocytes
Volume 6, Issue 1 , June 2022, , Pages 33-52
Abstract
Resumption of nuclear maturation and cytoplasmic changes occur during in vitro maturation. In vitro maturation of the egg provides a stage called Metaphase II (MII) that is required for in vitro fertilization. This study aimed to investigate the effect of replacing Follicle-Stimulating Hormone (FSH) ... Read MoreInflammation and Colorectal Cancer: The Bioinformatics Analysis of Multifunctional Role of Microbiota and Diet in Colorectal Cancer Development
Volume 5, Issue 4 , March 2022, , Pages 1-25
Abstract
Chronic inflammation in colorectal cancer can result in the progression of tumorigenesis. Inflammation in the colorectal part of the body can be affected by microbiota, as well as an individual diet. These two factors play a critical role in cancer types related to the colon and rectum. This inflammation ... Read MoreThe role of different genes in causing infection of ectodermal dysplasia patients: A systematic review
Volume 5, Issue 4 , March 2022, , Pages 86-104
Abstract
Ectodermal dysplasia (ED) is a genetic disorder which is characterized by deficient tissues from ectoderm and mesoderm. In this systematic review, two researchers searched keywords such as Ectodermal Dysplasia and Hypohidrotic Ectodermal Dysplasia (HED) in Medline (PubMed), Scopus, and Web of Science ... Read MoreAdjustment of expression of TUBB8, SOX9 and BCL2 genes in apoptosis and polycystic ovarian cancer
Volume 5, Issue 4 , March 2022, , Pages 105-154