Biological sciences
The Golden Doses of Anti CD3/CD28 Microbeads Plus IL-15 Promote Expansion of Specific T Cells in Human Cytomegalovirus Adaptive Immunotherapy

Arsalan Jalili; Nasser Aghdami; Abbas Hajifathali; Maryam Sayahinouri

Articles in Press, Accepted Manuscript, Available Online from 14 March 2023

https://doi.org/10.22034/hbb.2023.386576.1075

Abstract
  Background: There are various mechanisms are being developed to expand Virus specific T lymphocytes. In this study, the use of anti-CD3/CD28 magnetic microbeads and IL-15 in the culture of T lymphocytes in vitro has a significant role in the proliferation and cytotoxicity of these cells. Materials and ...  Read More

Biological sciences
Polyherbal formulation: An alternative therapeutic approach to treat diabetic foot ulcer

Debasmita Dubey; Shakti Rath; Rajesh Kumar Meher; Siba Prasad Dalai; Jayant Kumar Dash; Santosh Kumar Swain

Volume 6, Issue 4 , March 2023, , Pages 1-13

https://doi.org/10.22034/HBB.2023.01

Abstract
  Diabetic Foot Ulcers (DFUs) are a common complication of poorly controlled diabetes and often become infected, termed diabetic foot infection. Despite using several multidisciplinary techniques, no significant cure is still achievable. So, it needs an alternative therapeutic approach to treat diabetic ...  Read More

Biological sciences
Induction and evaluation of influenza cell-mediated immune responses by HA2 subunit and bio adjuvant as a gene vaccine candidate

Sina Soleimani; Mohammadreza Ghorani

Volume 6, Issue 4 , March 2023, , Pages 56-66

https://doi.org/10.22034/HBB.2023.05

Abstract
  The stalk domain of influenza as Hemagglutinin 2 (HA2) is a conserved unit of HA and is a candidate for a vaccine construct. We designed HA2/Mx (Myxovirus Resistance) as bio adjuvant construct for vaccine candidates. After immunization of Razi Balb/c mice in DNA/prime/boost strategy, for determination ...  Read More

Biological sciences
Whole exome sequencing reveals the first c.7456C>T p.Arg2486X mutation in ATM gene in Iranian population

Saeed Dorgaleleh; Karim Naghipoor; Teymoor Khosravi; Amin Tadayoni Nia; Elham Sheikhi Ghayur; Hamayon abdul Aziz; Morteza Oladnabi

Volume 6, Issue 3 , December 2022, , Pages 57-72

https://doi.org/10.22034/HBB.2022.23

Abstract
  Mutations in Ataxia-Telangiectasia Mutated (ATM) gene are prominently responsible for the condition. ATM gene encodes a serine/threonine protein kinase, a crucial component in DNA repair systems. Whole exome sequencing was performed on a nine year old male subject with clinical features of A-T. Alpha ...  Read More

Biological sciences
Ectodermal Dysplasia patients susceptible to COVID-19

Saeed Dorgaleleh; Karim naghipoor; Morteza Oladnabi

Volume 6, Issue 2 , September 2022, , Pages 78-80

https://doi.org/10.22034/HBB.2022.18

Abstract
  Ectodermal dysplasia (ED) is a rare heterogeneous disorder. Defects in the development of the ectoderm cause symptoms in tissues derived from the ectoderm layer such as skin, nails and hair. One of the genes involved in ED is Nuclear Factor Kappa-B (NF-κB) that mutation in this gene causes immunodeficiency. ...  Read More

Biological sciences
Biotransformation of atropine, 4-hydroxy coumarin, 8-hydroxy quinoline, indole and penicillin G by the natural microflora

Seyedeh Mahsa Hosseini; Raheem Haddad; Soroush Sardari

Volume 6, Issue 1 , June 2022, , Pages 13-25

https://doi.org/10.22034/HBB.2022.08

Abstract
  It has been found that natural microorganism have a siginificant role in the production and development of new medicines. The present study aimed to evaluat biotransformation of atropine, 4-hydroxy coumarin, 8-hydroxy quinoline, indole and industrially compound (penicillin G), arrive in the human body, ...  Read More

Biological sciences
The effect of Ajuga reptans extract on in vitro maturation of rat oocytes

Tina mandegarfard; Zahra Arabi; Mahsa Nejati; Nika Mashhadizadeh; Mina Nikandish; Mehdi Ahmadifar

Volume 6, Issue 1 , June 2022, , Pages 33-52

https://doi.org/10.22034/HBB.2022.10

Abstract
  Resumption of nuclear maturation and cytoplasmic changes occur during in vitro maturation. In vitro maturation of the egg provides a stage called Metaphase II (MII) that is required for in vitro fertilization. This study aimed to investigate the effect of replacing Follicle-Stimulating Hormone (FSH) ...  Read More

Biological sciences
Inflammation and Colorectal Cancer: The Bioinformatics Analysis of Multifunctional Role of Microbiota and Diet in Colorectal Cancer Development

Mohammad Ali Pahlevan Neshan; Payam Shahnazi Gerdehsang; Ahmad Bereimipour; Nazila Bostanshirin; Haniyeh Sadat Hosseininia; Kaykhosro Moridi; Amin Ebrahimi Sadrabadi; Arsalan Jalili

Volume 5, Issue 4 , March 2022, , Pages 1-25

https://doi.org/10.22034/HBB.2022.01

Abstract
  Chronic inflammation in colorectal cancer can result in the progression of tumorigenesis. Inflammation in the colorectal part of the body can be affected by microbiota, as well as an individual diet. These two factors play a critical role in cancer types related to the colon and rectum. This inflammation ...  Read More

Biological sciences
The role of different genes in causing infection of ectodermal dysplasia patients: A systematic review

Saeed Dorgaleleh; Zahra Toutounchi; Mahsa Soltani; Karim naghipoor; Morteza Oladnabi

Volume 5, Issue 4 , March 2022, , Pages 86-104

https://doi.org/10.22034/HBB.2022.05

Abstract
  Ectodermal dysplasia (ED) is a genetic disorder which is characterized by deficient tissues from ectoderm and mesoderm. In this systematic review, two researchers searched keywords such as Ectodermal Dysplasia and Hypohidrotic Ectodermal Dysplasia (HED) in Medline (PubMed), Scopus, and Web of Science ...  Read More

Biological sciences
Adjustment of expression of TUBB8, SOX9 and BCL2 genes in apoptosis and polycystic ovarian cancer

Mehdi Ahmadifar; Mina Nikandish; Nika Mashhadizadeh; Mohammad Hossein Azhir; sadaf reihani; ghazal hakiminezhad

Volume 5, Issue 4 , March 2022, , Pages 105-154

https://doi.org/10.22034/HBB.2022.06

Abstract
  Polycystic Ovary Syndrome (PCOS) is the most common heterogeneous Endocrine (EC) disorder in women of childbearing age, which has an increasing trend in the number of patients recently. Although women with PCOS have been shown to triple the risk of EC compared to women without polycystic ovary syndrome, ...  Read More