Ectodermal dysplasia (ED) is a rare heterogeneous disorder. Defects in the development of the ectoderm cause symptoms in tissues derived from the ectoderm layer such as skin, nails and hair. One of the genes involved in ED is Nuclear Factor Kappa-B (NF-κB) that mutation in this gene causes immunodeficiency. There are also some ED subgroups such as X-Link Hypohidrotic Ectodermal Dysplasia (XLHED) at risk of severe pneumonia and respiratory infections. The patients with ED due to the susceptibility of the immune system defect as well as the respiratory system, we hypothesized that these patients are sensitive to COVID -19. So the main organ involved in the respiratory system and the main cause of mortality in patients with COVID-19 is the respiratory system involvement. Therefore, they are at higher risk of developing symptomatic COVID-19 that requires further clinical care.