Document Type : Review Article

Authors

• Mohammad Ali Pahlevan Neshan ¹
• Payam Shahnazi Gerdehsang ²
• Ahmad Bereimipour ³
• Nazila Bostanshirin ⁴
• Haniyeh Sadat Hosseininia ⁵
• Kaykhosro Moridi ⁶
• Amin Ebrahimi Sadrabadi ³
• Arsalan Jalili ³

¹ Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

² Department of Biology, Islamic Azad University, Damghan Branch, Damghan, Iran

³ Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

⁴ Department of Microbiology, School of Medicine Science, Alborz University of Medical Science, Alborz, Iran.

⁵ Department of Cellular and Molecular Biology, Faculty of Advanced Medical Science, Tehran Islamic Azad University of Medical Sciences, Tehran, Iran

⁶ Department of Nanotechnology, Azad University of Pharmaceutical Sciences, Tehran, Iran

Abstract

Chronic inflammation in colorectal cancer can result in the progression of tumorigenesis. Inflammation in the colorectal part of the body can be affected by microbiota, as well as an individual diet. These two factors play a critical role in cancer types related to the colon and rectum. This inflammation could lose the protective epithelial layer of colorectal cancerous cells and, thus, translocation of healthy flora to inner layers. Pathogenic bacteria can also cause inflammation induction and tumorigenesis in the intestines. A change in the bacteria composition and some bacteria metabolites can also play a role in colorectal cancer. Dysbiosis can be affected by an individual diet. In this paper, the importance of diet and microbiota content on inflammation has been reviewed, and finally, in silico investigation confirmed their interplay.

Keywords

• Colorectal cancer
• Microbiota
• Inflammation
• Diet
• Bioinformatics analysis

Main Subjects

• Biological sciences