Chronic inflammation in colorectal cancer can result in the progression of tumorigenesis. Inflammation in the colorectal part of the body can be affected by microbiota, as well as an individual diet. These two factors play a critical role in cancer types related to the colon and rectum. This inflammation could lose the protective epithelial layer of colorectal cancerous cells and, thus, translocation of healthy flora to inner layers. Pathogenic bacteria can also cause inflammation induction and tumorigenesis in the intestines. A change in the bacteria composition and some bacteria metabolites can also play a role in colorectal cancer. Dysbiosis can be affected by an individual diet. In this paper, the importance of diet and microbiota content on inflammation has been reviewed, and finally, in silico investigation confirmed their interplay.