Diabetic foot ulcers (DFUs) are a common complication of poorly controlled diabetes and often become infected, termed diabetic foot infection. Despite using several multidisciplinary techniques, no significant cure is still achievable. So, it needs an alternative therapeutic approach to treat diabetic foot ulcers. Moreover, with the advent of multidrug resistance bacteria, the effectiveness of broad-spectrum antibiotics to treat DFUs has become an uphill task. So, it becomes a primary concern to search for alternative highly effective nontoxic drugs/polyhedral formulations from plants to treat DFUs. Although a considerable amount of work has been reported on developing a herbal formulation to treat DFUs, no serious attempt has been made to combat DFUs infected with MDR strains. This article provides a review of possible plants and research pathways that can be used to formulate an effective and safe herbal formulation to treat DFUs.