Pharmaceutical sciences
Comparison of methyl isoeugenol and methyl eugenol as renewable starting reagents for the synthesis of thiourea compounds for anti-Plasmodium falciparum

Warsito Warsito; Elvina Dhiaul Iftitah; Nashi Widodo; Nuryamin Kazal; Lucy - Arianie

Volume 7, Issue 4 , March 2024, Pages 1-23

https://doi.org/10.22034/HBB.2024.01

Abstract
  Several thiourea derivative compounds have been used as inhibitors of Plasmodium falciparum via the plasmepsin inhibition pathway. The thiourea derivative (compound 3) namely 1-{1-(3,4-dimethoxyphenyl)-4.6-bis[(3,4-dimethoxyphenyl)methyl]heptane-2-yl]-3-{[ (2E)-3-phenylprop-2-en-1-ylium-1-yl]amino}thiourea ...  Read More

Biological sciences
GC/MS analysis and antifungal activity of M. Chamomilla extracts against molecularly identified keratinophilic fungi

Afrah Talib Abdullah; kadhim F Kadhim

Volume 7, Issue 4 , March 2024, Pages 24-43

https://doi.org/10.22034/HBB.2024.02

Abstract
  The objective of this study was to isolate and genetically identify keratinophilic fungi associated with humans, test their susceptibility to nystatin, and evaluate the effectiveness of Methanol Extract (ME) from chamomile flowers against these fungi. No cytotoxic effects were observed in the extract ...  Read More

Biological sciences
Parameter changes of COVID-19 incidence in Baghdad/Iraq in 2020: Infected and cured individuals: A retrospective single center study

noah mahmood; zaynab abdulghany

Volume 7, Issue 4 , March 2024, Pages 44-62

https://doi.org/10.22034/HBB.2024.03

Abstract
  Coronavirus disease 2019 (COVID-19) represented a highly respiratory syndrome to worldwide. Aim of current research was to determine the changes in hematology and inflammatory parameters into three categories: non-infected with COVID-19 as control groups, infected with COVID-19 and cured from the disease ...  Read More

Biological sciences
Investigating the effects of Zataria Multiflora essential oil and silver nanoparticles on the expression of abaI and pil genes in Acinetobacter baumannii biofilm formation

Saghar Bakhtiari; Fatemeh Noorbakhsh; Sadaf Mohseni Fard; Raheleh Safaei javan

Volume 7, Issue 4 , March 2024, Pages 63-80

https://doi.org/10.22034/HBB.2024.04

Abstract
  The aim of this research was to investigate the effect of Zataria multiflora and silver nanoparticles on the biofilm formation ability of A. baumannii and the expression of genes involved in this process. Thirty isolates of A. baumannii bacteria were collected and studied from the Milad Hospital of Tehran. ...  Read More

Biological sciences
Biofilm formation and drug resistance determinants of Moraxella catarrhalis, Moraxella osloensis and Moraxella lacunata from clinical samples in Iraq

Manal Hadi Ghaffoori Kanaan; Hiba Riyadh Al-abodi; Sura Saad Abdullah; Mojtaba Memariani; Maryam Kohansal; Abdolmajid Ghasemian

Volume 7, Issue 4 , March 2024, Pages 81-97

https://doi.org/10.22034/HBB.2024.05

Abstract
  In this study, fifty Moraxella species were isolated. The antibiotic susceptibility, β-lactamases and minimum inhibitory and bactericidal concentrations were evaluated. The rate of ESBLs among M. catarrhalis, M. osloensis and M. lacunata included 47 % (n=11), 36.84 % (n=7) and 37.5 % (n=3), respectively. ...  Read More

Pharmaceutical sciences
Ipragliflozin protect from acute pulmonary injury induced by endotoxemia in mouse model via NF-KB pathway

Noor Adnan Najm; Ekhlas Sabah Hassan

Volume 7, Issue 4 , March 2024, Pages 98-113

https://doi.org/10.22034/HBB.2024.06

Abstract
  Sepsis is now more commonly regarded as an uncontrolled inflammatory and immune response throughout the body, triggered by microbial invasion and resulting in high mortality rate from organ damage. This study aimed to demonstrate the protective impact of ipragliflozin on lung damage induced in mice by ...  Read More