Document Type : Review Article

Authors

• Saeed Dorgaleleh ¹
• Zahra Toutounchi ²
• Mahsa Soltani ²
• Karim naghipoor ¹
• Morteza Oladnabi ³

¹ Golestan University of Medical Sciences

² Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran

³ Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran

Abstract

Ectodermal dysplasia (ED) is a genetic disorder which is characterized by deficient tissues from ectoderm and mesoderm. In this systematic review, two researchers searched keywords such as Ectodermal Dysplasia and Hypohidrotic Ectodermal Dysplasia (HED) in Medline (PubMed), Scopus, and Web of Science databases were searched until June 2020. In the first search 885 articles were found. After including and excluding criteria, included articles were reduced to 53 in Scopus, 11 in Web of Science, and 11 in PubMed. The point is that out of 75 selected studies, 52 articles were identified the cause of infection in ectodermal dysplasia as mutations in the NEMO gene and its subsets.

Keywords

• Ectodermal dysplasia
• infection
• immunodeficiency
• NEMO
• NF-KB

Main Subjects

• Biological sciences