Document Type : Original Research Article

Authors

• Mahdi Zarei ¹
• Mohsen Soroush ²
• Saeed Mohammadi ³

¹ Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran

² Department of Rheumatology, AJA University of Medical Sciences, Tehran, Iran

³ Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.

Abstract

Numerous studies have examined the effect of genetic variations in the Toll-Like Receptor 9 (TLR9) on the development of Systemic Lupus Erythematosus (SLE). An allele-specific PCR technique was employed to analyze the genetic variation in the study participants in a cohort of SLE and healthy controls from the Golestan region of northern Iran. Our study revealed no statistically significant variations in genotype and allele distribution between individuals with SLE and the control group. When analyzing the genotype frequency for rs352139, no significant association was observed between the GA genotype and AA genotype in relation to the risk of developing SLE, using the GG genotype as the reference. These findings indicated that the TLR9 rs352139 SNP could not play a significant role in determining susceptibility to SLE.

Keywords

• Toll-like receptor 9 (TLR9)
• genetic variations
• polymorphism

Main Subjects

• Biological sciences