Pharmaceutical sciences
A new frontier: Unveiling the possibility of targeting intracellular antigens with nucleic acid aptamers

Zahra Salimi; Mohammad Ahmadyousefi

Volume 7, Issue 3 , December 2023, Pages 1-9

https://doi.org/10.22034/HBB.2023.20

Abstract
  Proven RNA-based medications have elevated the demand for targeted nucleic acid-based agents. In this study, nucleic acid aptamers represented an appropriate class of molecules. They are single-stranded nucleic acid molecules that bind to a target molecule with high affinity and specificity. Aptamers ...  Read More

Biological sciences
EZH2 expression role in angiogenesis of prostate malignancy

Sanaz Kavoosi; Sanam Rezazadeh Chafjiri; Nastaran Asghari Moghaddam

Volume 7, Issue 3 , December 2023, Pages 10-29

https://doi.org/10.22034/HBB.2023.21

Abstract
  The gene Enhancer of Zeste Homolog 2 (EZH2) is shown to be involved in the progression of the angiogenesis in cancer including prostate cancer, also it is a well-known enzyme catalytic subunit, initially acting as a histone methyltransferase, to prevent expressing gene by trimethylating lysine at the ...  Read More

Medicinal sciences
Bibliometric analysis: The future of thalassemia disease by utilizing artificial intelligence technology

Erliyan Redy Susanto; Admi Syarif; Warsito Warsito; Khairun Nisa Berawi; Hidayat Hidayat

Volume 7, Issue 3 , December 2023, Pages 30-44

https://doi.org/10.22034/HBB.2023.22

Abstract
  The use of artificial intelligence to solve surfaces in thalassemia disease has been the focus of popular research in the last decade. However, there are no scientific reports that provide a systematic overview of this scientific field. We used bibliometric approaches to identify and analyze academic ...  Read More

Biological sciences
Exploring bacillus subtilis isolated from soil as a promising alternative for L-asparaginase enzyme production

Seyed Mohammad Haji Mirghasemi; Hamid Reza Pordeli; Leila Fozouni; Mina Komshikamar; fatemeh komshikamar; Mansoor Rubin

Volume 7, Issue 3 , December 2023, Pages 45-61

https://doi.org/10.22034/HBB.2023.23

Abstract
  In this study, eight bacterial isolates were obtained from the 35 soil samples of Golestan province in Iran. Samples were collected from different soils and cultured in an M9 medium. Enzyme-producing colonies were distinguished by the color change from yellow to pink. 16s rRNA sequencing identified L-asparaginase ...  Read More

Pharmaceutical sciences
Introducing an innovative algorithm based on the abilities of the human perception system towards profiling similarity search of drugs and drug-like compounds such as fluoxetine

Setareh Ghavami; Ghazaleh Ghavami; Hassan Toozandehjani; Soroush Sardari

Volume 7, Issue 3 , December 2023, Pages 62-76

https://doi.org/10.22034/HBB.2023.24

Abstract
  The current research had been finalized based on the employing interdisciplinary aspects in addition to utilizing skills of cheminformatics in addition to psychosomatic facts towards introducing the innovative Translator Machine System (TMS-CH) for converting small molecule structures to melodic composition ...  Read More

Biological sciences
Investigating the association between Toll-Like Receptor 9 (TLR9) rs352139 genetic variants and Systemic Lupus Erythematosus (SLE) in an Iranian population

Mahdi Zarei; Mohsen Soroush; Saeed Mohammadi

Volume 7, Issue 3 , December 2023, Pages 77-91

https://doi.org/10.22034/HBB.2023.25

Abstract
  Numerous studies have examined the effect of genetic variations in the Toll-Like Receptor 9 (TLR9) on the development of Systemic Lupus Erythematosus (SLE). An allele-specific PCR technique was employed to analyze the genetic variation in the study participants in a cohort of SLE and healthy controls ...  Read More