Mohadeseh Nemati; Fahima Danesh Pouya; Fateme Zarein; Mahdieh Nemati; Yousef Rasmi; Jafar Rezaie; Tooba Hallaj
Abstract
Cancer cells are metabolically different from normal cells, including the Warburg effect and uses glutamine to fill the Tricarboxylic Acid (TCA) cycle. It was demonstrated inhibiting glutamine metabolism prevents tumor growth. The mammalian Target of Rapamycin (mTOR) is one of the signaling pathways ...
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Cancer cells are metabolically different from normal cells, including the Warburg effect and uses glutamine to fill the Tricarboxylic Acid (TCA) cycle. It was demonstrated inhibiting glutamine metabolism prevents tumor growth. The mammalian Target of Rapamycin (mTOR) is one of the signaling pathways that involve glutamine metabolism in cancer. Carbon Quantum dots (CQ-dots) nanoparticles are associated with the mTOR signaling pathway. These findings indicate that irregular glutamine metabolism are related to the growth of Colorectal Cancer (CRC). Thus, the activating glutamine metabolism via the mTOR pathway in CQ-dots treatments has toxic effect on CRC therapy. So, more investigations need for therapeutic application of these nanocarriers.
Medicinal sciences
Nastaran Sahraei; Mina Mobin Rahni; Mehdi Ahmadifar
Abstract
Leukemia as one of the common cancers is still studied and needs improvement in diagnosis and treatment. In this study, we examined the activity of hematopoietic stem cells, which can be a precursor to leukemia. Hematopoietic cancer cells, by affecting the bone marrow, preserve the source of stem cells ...
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Leukemia as one of the common cancers is still studied and needs improvement in diagnosis and treatment. In this study, we examined the activity of hematopoietic stem cells, which can be a precursor to leukemia. Hematopoietic cancer cells, by affecting the bone marrow, preserve the source of stem cells for the development of blood cancers. Also, in this study, various signaling pathways, including Wnt, which regulates the production of blood cells, and the abnormal expression and function of miRNAs in leukemia were investigated. We also analyzed various cellular and molecular factors that play a role in the occurrence of leukemia, as well as further studies in the field of cancer and immunology, which can lead to the discovery of new treatments and improve the function of the body's immune system against cancer cells.
Seyed Hossein Shahcheraghi; Mahdie Hamidfar; Faezehsadat Heidari; Sajjad Shahmohammadi; Zohre Akhondimeybodi; Tahere Fallah; Yegane Aliakbarzade Yazdani
Abstract
Mucormycosis in COVID-19 patients of severe type has been reported. This study was intended to evaluate ESR, CRP, LDH, CPK, D-Dimer, BS and FBS levels in COVID-19 patients with mucormycosis. Information was recorded including gender, age, hospitalization and recovery. The laboratory parameters contained ...
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Mucormycosis in COVID-19 patients of severe type has been reported. This study was intended to evaluate ESR, CRP, LDH, CPK, D-Dimer, BS and FBS levels in COVID-19 patients with mucormycosis. Information was recorded including gender, age, hospitalization and recovery. The laboratory parameters contained ESR, CRP, LDH, CPK, D-Dimer, BS and FBS levels. There was a significant relationship between LDH and CPK level with hospitalization, and also, between CRP and gender. Finally, there was a significant difference between the age groups in terms of ESR. Our study showed that LDH and CPK, CRP and ESR should be considered as laboratory tests in the hospitalized COVID-19 patients with mucormycosis.
Zohreh AkhoundiMeybodi; Mohammad Sharifyazdi; Reyhane Shaterian; bijan jafarnia; kazem ansari
Abstract
The aim of this study was to compare active and passive surveillance methods. This descriptive cross-sectional study was conducted on 296 patients who were admitted to Shahid Sadoughi hospital in Yazd from 2018 to 2020. Surveillance for signs of Surgical Site Infection (SSI) was done using passive (via ...
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The aim of this study was to compare active and passive surveillance methods. This descriptive cross-sectional study was conducted on 296 patients who were admitted to Shahid Sadoughi hospital in Yazd from 2018 to 2020. Surveillance for signs of Surgical Site Infection (SSI) was done using passive (via pamphlet) and active (by telephone) methods in two months. Among 296 patients, SSI was seen in 67 patients (22.6 %). The frequency of SSI in active and passive methods was 65 (24 %) and 2 patients (8 %), respectively. Significant difference was seen between two care methods (p<0.05). According to these findings, the active care method was superior to passive method in diagnosis of SSI. Therefore, this method can be used for early detection of infection to reduce complications.
Maryam Naderi Mezajin; Mahdi Fatemizadeh; Zahra Rostami; Pejvak Khaki; Masoomeh Shirzad; Fatemeh Noorbakhsh
Abstract
The aim of this study was to investigate the antibiotic resistance and identification of strains producing broad-spectrum beta-lactamases salmonella strains. The 70 different strains of salmonella were studied that gentamicin, ciprofloxacin, ofloxacin, imipenem, and enrofloxacin were susceptible. The ...
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The aim of this study was to investigate the antibiotic resistance and identification of strains producing broad-spectrum beta-lactamases salmonella strains. The 70 different strains of salmonella were studied that gentamicin, ciprofloxacin, ofloxacin, imipenem, and enrofloxacin were susceptible. The highest resistance to cephalexin (96 %), cefazolin (96 %), cephalothin (65 %), and 69 isolates (98 %), were resistant to more than one antibiotic. The results of the Polymerase Chain Reaction (PCR) were evaluated on ESBL producing isolates using specific primers; in order to investigate the presence of CTX-Mbla, SHVbla, TEMbla and OXAbla, so the presence of germ cell resistance genes in total indicated that 32 isolates (56 %), at least one of the above genes.
Biological sciences
Saeed Dorgaleleh; Karim naghipoor; Morteza Oladnabi
Abstract
Ectodermal dysplasia (ED) is a rare heterogeneous disorder. Defects in the development of the ectoderm cause symptoms in tissues derived from the ectoderm layer such as skin, nails and hair. One of the genes involved in ED is Nuclear Factor Kappa-B (NF-κB) that mutation in this gene causes immunodeficiency. ...
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Ectodermal dysplasia (ED) is a rare heterogeneous disorder. Defects in the development of the ectoderm cause symptoms in tissues derived from the ectoderm layer such as skin, nails and hair. One of the genes involved in ED is Nuclear Factor Kappa-B (NF-κB) that mutation in this gene causes immunodeficiency. There are also some ED subgroups such as X-Link Hypohidrotic Ectodermal Dysplasia (XLHED) at risk of severe pneumonia and respiratory infections. The patients with ED due to the susceptibility of the immune system defect as well as the respiratory system, we hypothesized that these patients are sensitive to COVID -19. So the main organ involved in the respiratory system and the main cause of mortality in patients with COVID-19 is the respiratory system involvement. Therefore, they are at higher risk of developing symptomatic COVID-19 that requires further clinical care.
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