Health Biotechnology and Biopharma  


Health Biotechnology and Biopharma (HBB, ISSN: 2538-4414) is a quarterly peer-reviewed journal which promotes latest research which emphasizes on all areas of health biotechnology and biopharma. It is an open access, peer-reviewed and online scientific journal. The aim of this journal is to provide a platform for researchers to promote innovative research. This journal consists of the following sections:

• BioPharm Hypothesis

• Original Research/ Review Article

• Short Communication/ Opinion/ Letter

In the field of pharmaceutical, biological, medicinal and chemical sciences. Bio/Pharm Hypothesis provides novel and innovative ideas in biopharmaceutics, opening the field to radical hypothesis based on non-experimental and experimental research. We assign all articles to Digital Object Identifier (DOI ) of mEDRA. Please submit your manuscript online. There is a processing fee per each article accepted. Similarities of the received manuscripts have been checked by iThenticate to evaluate plagiarism.

Pharmaceutical sciences
Comparison of methyl isoeugenol and methyl eugenol as renewable starting reagents for the synthesis of thiourea compounds for anti-Plasmodium falciparum

Warsito Warsito; Elvina Dhiaul Iftitah; Nashi Widodo; Nuryamin Kazal; Lucy - Arianie

Volume 7, Issue 4 , March 2024, Pages 1-23

  Several thiourea derivative compounds have been used as inhibitors of Plasmodium falciparum via the plasmepsin inhibition pathway. The thiourea derivative (compound 3) namely 1-{1-(3,4-dimethoxyphenyl)-4.6-bis[(3,4-dimethoxyphenyl)methyl]heptane-2-yl]-3-{[ (2E)-3-phenylprop-2-en-1-ylium-1-yl]amino}thiourea ...  Read More

Biological sciences
GC/MS analysis and antifungal activity of M. Chamomilla extracts against molecularly identified keratinophilic fungi

Afrah Talib Abdullah; kadhim F Kadhim

Volume 7, Issue 4 , March 2024, Pages 24-43

  The objective of this study was to isolate and genetically identify keratinophilic fungi associated with humans, test their susceptibility to nystatin, and evaluate the effectiveness of Methanol Extract (ME) from chamomile flowers against these fungi. No cytotoxic effects were observed in the extract ...  Read More

Biological sciences
Parameter changes of COVID-19 incidence in Baghdad/Iraq in 2020: Infected and cured individuals: A retrospective single center study

noah mahmood; zaynab abdulghany

Volume 7, Issue 4 , March 2024, Pages 44-62

  Coronavirus disease 2019 (COVID-19) represented a highly respiratory syndrome to worldwide. Aim of current research was to determine the changes in hematology and inflammatory parameters into three categories: non-infected with COVID-19 as control groups, infected with COVID-19 and cured from the disease ...  Read More

Biological sciences
Investigating the effects of Zataria Multiflora essential oil and silver nanoparticles on the expression of abaI and pil genes in Acinetobacter baumannii biofilm formation

Saghar Bakhtiari; Fatemeh Noorbakhsh; Sadaf Mohseni Fard; Raheleh Safaei javan

Volume 7, Issue 4 , March 2024, Pages 63-80

  The aim of this research was to investigate the effect of Zataria multiflora and silver nanoparticles on the biofilm formation ability of A. baumannii and the expression of genes involved in this process. Thirty isolates of A. baumannii bacteria were collected and studied from the Milad Hospital of Tehran. ...  Read More

Biological sciences
Biofilm formation and drug resistance determinants of Moraxella catarrhalis, Moraxella osloensis and Moraxella lacunata from clinical samples in Iraq

Manal Hadi Ghaffoori Kanaan; Hiba Riyadh Al-abodi; Sura Saad Abdullah; Mojtaba Memariani; Maryam Kohansal; Abdolmajid Ghasemian

Volume 7, Issue 4 , March 2024, Pages 81-97

  In this study, fifty Moraxella species were isolated. The antibiotic susceptibility, β-lactamases and minimum inhibitory and bactericidal concentrations were evaluated. The rate of ESBLs among M. catarrhalis, M. osloensis and M. lacunata included 47 % (n=11), 36.84 % (n=7) and 37.5 % (n=3), respectively. ...  Read More

Pharmaceutical sciences
Ipragliflozin protect from acute pulmonary injury induced by endotoxemia in mouse model via NF-KB pathway

Noor Adnan Najm; Ekhlas Sabah Hassan

Volume 7, Issue 4 , March 2024, Pages 98-113

  Sepsis is now more commonly regarded as an uncontrolled inflammatory and immune response throughout the body, triggered by microbial invasion and resulting in high mortality rate from organ damage. This study aimed to demonstrate the protective impact of ipragliflozin on lung damage induced in mice by ...  Read More

Medicinal sciences
Best insights on target molecules for drug design of nCOVID-19 based on pharmacological and peptide-based therapeutics

Seyed Hossein Shahcheraghi; Venant Tchokonte-Nana; Jamshid Ayatollahi; Marzieh Lotfi; Mahdie Hamidfar; Benjamin Longo-Mbenza

Volume 6, Issue 1 , June 2022, , Pages 62-81

  Coronavirus is a non-segmented virus related to Coronaviridae family with an envelope and RNA that has a huge positive-sense single-stranded genome. The causative agent of COVID-19, severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2) first appeared in China in 2019. The role of these viruses ...  Read More

Pharmaceutical sciences
DNA damage protection by fatty acid rich fractions from Andrographis Paniculata Nees (AP): An in vitro study

Pravin D Badhe; Ashwini Badhe; Kajal Nadaf; Srushti Deshmukh; Kishor Otari

Volume 5, Issue 4 , March 2022, , Pages 55-85

  As antioxidants prevent free radical caused DNA damage, they lower the risk of developing chronic diseases. The present study evaluated the impact of fatty acid-rich fractions of Andrographis Paniculata Nees (AP) on free radical-induced DNA damage. We prepared fatty acid-rich fractions with dried AP ...  Read More

Hypothesis of a potential antiviral drug

Kevin Ricardo Espinosa

Volume 6, Issue 3 , December 2022, , Pages 1-10

  The approval of mRNA vaccine technique against COVID-19 opens a door to research and the creation of new drugs against different infectious pathologies or even cancer, since for several diseases the therapeutic options are limited, and different viral diseases are treated only symptomatically. For these ...  Read More

New insights into the effects of hydroxychloroquine in COVID-19
Volume 5, Issue 2 , September 2021, , Pages 1-6

  In late 2019 until 2021, the novel coronavirus disease (COVID-19) has become pandemic. This disease is related to severe inflammatory symptoms of the respiratory epithelial cells and the dysfunction of several organs. One of the suggested drugs to reduce the inflammation caused by COVID-19 is hydroxychloroquine. ...  Read More

Association of non-synonymous +326 A>T and synonymous +258 G>A polymorphisms of omentin-1 gene (ITLN-1) among type 2 diabetes patients of Pakistan
Volume 5, Issue 2 , September 2021, , Pages 46-60

  Omentin is an adipocytokine that has anti-diabetic property. Genetic variations in ITLN-1 may affect blood glucose level by inactivating Akt/PKB signaling pathway. The aim of this study was to evaluate the association between ITLN-1 gene non-synonymous +326 A>T and synonymous +258 G>A polymorphisms ...  Read More

Medicinal sciences
Investigating the Effect of Artemisia oucheri Plant Essential Oil on the Level of Liver Enzymes in Rats Affected by Paracetamol

Ani Boghozian; Ali Choopani; Hamid Reza Shiran; Amirhossein Choopani; Nahid Ghaedamini

Articles in Press, Accepted Manuscript, Available Online from 12 March 2024

  The purpose of this study was to investigate the effect of Artemisia Ouchei on the liver enzymes of post -treatment with paracetamol. Artemisia was collected from Kashan area in Iran. The flower Essential Oil of this plant was extracted using a cloner device and the components of it were separated and ...  Read More

Biological sciences
The association of the human papilloma virus genotypes and telomerase gene polymorphisms in cervical lesion

Elaheh Gholami Roudmajan; Ali H. Al-Marzoqi; Miaad K. Alkhudhairy; Maryam Kohansal; Abdolmajid Ghasemian; Seyed Masoud Houshmand

Articles in Press, Accepted Manuscript, Available Online from 07 April 2024

  A leading risk factor for cervical cancer (CC) initiation and progress includes human papillomavirus (HPV) infection. The telomerase catalytic subunit which regulates senescence and proliferation (carcinogenesis) is encoded by human telomerase reverse transcriptase (hTERT) gene. Our objective was the ...  Read More

Biological sciences
Elucidating the Probiotic Function of Lactic Acid Bacteria in Aflatoxin Mitigation from Dairy Products

Miaad K. Alkhudhairy; Rasha Fadhel Obaid; Haider Qassim Raheem; Ahmad Shaya Kareem; Hamidreza Kianfar; Mojtaba Memariani; Maryam Kohansal; Ali Taghinezhad

Articles in Press, Accepted Manuscript, Available Online from 14 April 2024

  Dairy products are susceptible to contamination by various microorganisms, including fungal species, throughout the production, distribution, and storage phases, primarily due to non-compliance with hygienic standards. Notably, fungal microorganisms exhibit resilience to acidic and low-temperature environments, ...  Read More

Biological sciences
Effect of Dates (Phoenix dactylifera) Juice on Anemia in TB Infected Patients Undergoing Tuberculosis Treatment

Sri Ujiani; Sri Nuraini

Articles in Press, Accepted Manuscript, Available Online from 27 April 2024

  This study investigates the efficacy of dates palm juice in alleviating anemia among 100 tuberculosis patients undergoing treatment. Participants from four public health centers in Bandar Lampung were divided into control (n=25) and treatment groups (n=75). The treatment groups received tuberculosis ...  Read More

Biological sciences
Differential expression of lymph node metastasis pathway genes in two subtypes of triple negative breast cancer cells

Shirin Shahbazi; Reza Mahdian

Articles in Press, Accepted Manuscript, Available Online from 14 May 2024

  Background: The survival rate for triple-negative breast cancer with metastasis is generally lower than other types of breast cancer. Finding specific molecular markers for timely determination of lymph node metastasis is of great importance. Methods: We investigated the transcriptome profiles of two ...  Read More