Health Biotechnology and Biopharma  

 

Health Biotechnology and Biopharma (HBB, ISSN: 2538-4414) is a quarterly peer-reviewed journal which promotes latest research which emphasizes on all areas of health biotechnology and biopharma. It is an open access, peer-reviewed and online scientific journal. The aim of this journal is to provide a platform for researchers to promote innovative research. This journal consists of the following sections:

• BioPharm Hypothesis

• Original Research/ Review Article

• Short Communication/ Opinion/ Letter

In the field of pharmaceutical, biological, medicinal and chemical sciences. Bio/Pharm Hypothesis provides novel and innovative ideas in biopharmaceutics, opening the field to radical hypothesis based on non-experimental and experimental research. We assign all articles to Digital Object Identifier (DOI ) of mEDRA. Please submit your manuscript online. There is a processing fee per each article accepted. Similarities of the received manuscripts have been checked by iThenticate to evaluate plagiarism.

Pharmaceutical sciences
A new frontier: Unveiling the possibility of targeting intracellular antigens with nucleic acid aptamers

Zahra Salimi; Mohammad Ahmadyousefi

Volume 7, Issue 3 , December 2023, Pages 1-9

https://doi.org/10.22034/HBB.2023.20

Abstract
  Proven RNA-based medications have elevated the demand for targeted nucleic acid-based agents. In this study, nucleic acid aptamers represented an appropriate class of molecules. They are single-stranded nucleic acid molecules that bind to a target molecule with high affinity and specificity. Aptamers ...  Read More

Biological sciences
EZH2 expression role in angiogenesis of prostate malignancy

Sanaz Kavoosi; Sanam Rezazadeh Chafjiri; Nastaran Asghari Moghaddam

Volume 7, Issue 3 , December 2023, Pages 10-29

https://doi.org/10.22034/HBB.2023.21

Abstract
  The gene Enhancer of Zeste Homolog 2 (EZH2) is shown to be involved in the progression of the angiogenesis in cancer including prostate cancer, also it is a well-known enzyme catalytic subunit, initially acting as a histone methyltransferase, to prevent expressing gene by trimethylating lysine at the ...  Read More

Medicinal sciences
Bibliometric analysis: The future of thalassemia disease by utilizing artificial intelligence technology

Erliyan Redy Susanto; Admi Syarif; Warsito Warsito; Khairun Nisa Berawi; Hidayat Hidayat

Volume 7, Issue 3 , December 2023, Pages 30-44

https://doi.org/10.22034/HBB.2023.22

Abstract
  The use of artificial intelligence to solve surfaces in thalassemia disease has been the focus of popular research in the last decade. However, there are no scientific reports that provide a systematic overview of this scientific field. We used bibliometric approaches to identify and analyze academic ...  Read More

Biological sciences
Exploring bacillus subtilis isolated from soil as a promising alternative for L-asparaginase enzyme production

Seyed Mohammad Haji Mirghasemi; Hamid Reza Pordeli; Leila Fozouni; Mina Komshikamar; fatemeh komshikamar; Mansoor Rubin

Volume 7, Issue 3 , December 2023, Pages 45-61

https://doi.org/10.22034/HBB.2023.23

Abstract
  In this study, eight bacterial isolates were obtained from the 35 soil samples of Golestan province in Iran. Samples were collected from different soils and cultured in an M9 medium. Enzyme-producing colonies were distinguished by the color change from yellow to pink. 16s rRNA sequencing identified L-asparaginase ...  Read More

Pharmaceutical sciences
Introducing an innovative algorithm based on the abilities of the human perception system towards profiling similarity search of drugs and drug-like compounds such as fluoxetine

Setareh Ghavami; Ghazaleh Ghavami; Hassan Toozandehjani; Soroush Sardari

Volume 7, Issue 3 , December 2023, Pages 62-76

https://doi.org/10.22034/HBB.2023.24

Abstract
  The current research had been finalized based on the employing interdisciplinary aspects in addition to utilizing skills of cheminformatics in addition to psychosomatic facts towards introducing the innovative Translator Machine System (TMS-CH) for converting small molecule structures to melodic composition ...  Read More

Biological sciences
Investigating the association between Toll-Like Receptor 9 (TLR9) rs352139 genetic variants and Systemic Lupus Erythematosus (SLE) in an Iranian population

Mahdi Zarei; Mohsen Soroush; Saeed Mohammadi

Volume 7, Issue 3 , December 2023, Pages 77-91

https://doi.org/10.22034/HBB.2023.25

Abstract
  Numerous studies have examined the effect of genetic variations in the Toll-Like Receptor 9 (TLR9) on the development of Systemic Lupus Erythematosus (SLE). An allele-specific PCR technique was employed to analyze the genetic variation in the study participants in a cohort of SLE and healthy controls ...  Read More

Medicinal sciences
Best insights on target molecules for drug design of nCOVID-19 based on pharmacological and peptide-based therapeutics

Seyed Hossein Shahcheraghi; Venant Tchokonte-Nana; Jamshid Ayatollahi; Marzieh Lotfi; Mahdie Hamidfar; Benjamin Longo-Mbenza

Volume 6, Issue 1 , June 2022, , Pages 62-81

https://doi.org/10.22034/HBB.2022.12

Abstract
  Coronavirus is a non-segmented virus related to Coronaviridae family with an envelope and RNA that has a huge positive-sense single-stranded genome. The causative agent of COVID-19, severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2) first appeared in China in 2019. The role of these viruses ...  Read More

Pharmaceutical sciences
DNA damage protection by fatty acid rich fractions from Andrographis Paniculata Nees (AP): An in vitro study

Pravin D Badhe; Ashwini Badhe; Kajal Nadaf; Srushti Deshmukh; Kishor Otari

Volume 5, Issue 4 , March 2022, , Pages 55-85

https://doi.org/10.22034/HBB.2022.04

Abstract
  As antioxidants prevent free radical caused DNA damage, they lower the risk of developing chronic diseases. The present study evaluated the impact of fatty acid-rich fractions of Andrographis Paniculata Nees (AP) on free radical-induced DNA damage. We prepared fatty acid-rich fractions with dried AP ...  Read More

Hypothesis of a potential antiviral drug

Kevin Ricardo Espinosa

Volume 6, Issue 3 , December 2022, , Pages 1-10

https://doi.org/10.22034/HBB.2022.19

Abstract
  The approval of mRNA vaccine technique against COVID-19 opens a door to research and the creation of new drugs against different infectious pathologies or even cancer, since for several diseases the therapeutic options are limited, and different viral diseases are treated only symptomatically. For these ...  Read More

New insights into the effects of hydroxychloroquine in COVID-19
Volume 5, Issue 2 , September 2021, , Pages 1-6

https://doi.org/10.22034/HBB.2021.13

Abstract
  In late 2019 until 2021, the novel coronavirus disease (COVID-19) has become pandemic. This disease is related to severe inflammatory symptoms of the respiratory epithelial cells and the dysfunction of several organs. One of the suggested drugs to reduce the inflammation caused by COVID-19 is hydroxychloroquine. ...  Read More

Association of non-synonymous +326 A>T and synonymous +258 G>A polymorphisms of omentin-1 gene (ITLN-1) among type 2 diabetes patients of Pakistan
Volume 5, Issue 2 , September 2021, , Pages 46-60

https://doi.org/10.22034/HBB.2021.18

Abstract
  Omentin is an adipocytokine that has anti-diabetic property. Genetic variations in ITLN-1 may affect blood glucose level by inactivating Akt/PKB signaling pathway. The aim of this study was to evaluate the association between ITLN-1 gene non-synonymous +326 A>T and synonymous +258 G>A polymorphisms ...  Read More

Biological sciences
GC/MS Analysis and Antifungal Activity of M. Chamomilla Extracts Against Molecularly Identified Keratinophilic Fungi

Afrah Talib Abdullah; kadhim F Kadhim

Articles in Press, Accepted Manuscript, Available Online from 02 January 2024

https://doi.org/10.22034/hbb.2024.425343.1126

Abstract
  The objective of this study was to isolate and genetically identify keratinophilic fungi associated with humans, test their susceptibility to Nystatin, and evaluate the effectiveness of ME from chamomile flowers against these fungi. No cytotoxic effects were observed in the extract's cytotoxicity assay ...  Read More

Pharmaceutical sciences
Comparison of methyl isoeugenol and methyl eugenol as renewable starting reagents for the synthesis of thiourea compounds for anti-plasmodium falciparum

Warsito Warsito; Elvina Dhiaul Iftitah; Nashi Widodo; Nuryamin Kazal; Lucy - Arianie

Articles in Press, Accepted Manuscript, Available Online from 02 January 2024

https://doi.org/10.22034/hbb.2023.424445.1124

Abstract
  Several thiourea derivative compounds have been used as inhibitors of Plasmodium falciparum via the Plasmepsin inhibition pathway. The thiourea derivative (compound 3) namely 1-{1-(3,4-dimethoxyphenyl)-4.6-bis[(3,4-dimethoxyphenyl)methyl]heptane-2-yl]-3-{[ (2E)-3-phenylprop-2-en-1-ylium-1-yl]amino}thiourea ...  Read More

Biological sciences
Parameter Changes of covid -19 incidence in Baghdad /Iraq, 2020: infected and cured individuals: a retrospective single center study

noah mahmood; zaynab abdulghany

Articles in Press, Accepted Manuscript, Available Online from 06 January 2024

https://doi.org/10.22034/hbb.2024.426153.1127

Abstract
  Coronavirus disease 2019 (COVID-19) represented a highly respiratory syndrome to worldwide. current research was to determine the changes in hematology and inflammatory parameters into three categories: non-infected with covid-19 (n=37) as control groups, infected with covid-19 (n=146) and cured (n=54) ...  Read More

Biological sciences
Investigating the Effects of Zataria Multiflora Essential Oil and Silver Nanoparticles on the Expression of abaI and pil Genes and Biofilm Formation in Acinetobacter baumannii

Saghar Bakhtiari; Fatemeh Noorbakhsh; Sadaf Mohseni Fard; Raheleh Safaei javan

Articles in Press, Accepted Manuscript, Available Online from 13 January 2024

https://doi.org/10.22034/hbb.2024.428913.1131

Abstract
  objective: The aim of this research was to investigate the effect of Zataria multiflora and silver nanoparticles on the biofilm formation ability of A. baumannii and the expression of genes involved in this process. Methods: Thirty A. baumannii isolates were collected from the Milad Hospital of Tehran ...  Read More

Biological sciences
Biofilm formation and drug resistance determinants of Moraxella catarrhalis, Moraxella osloensis and Moraxella lacunata from clinical samples: First report from Iraq

Manal Hadi Ghaffoori Kanaan; Hiba Riyadh Al-abodi; a Salahi; gh Nikfar; m Memariani; maryam kohansal; m Ghasemian

Articles in Press, Accepted Manuscript, Available Online from 03 February 2024

https://doi.org/10.22034/hbb.2024.416210.1109

Abstract
  Moraxella spp are Gram-negative coccobacilli which primarily cause human infections. Biofilm formation is an indispensable cause of bacterial multidrug resistance (MDR). In this study, biofilm formation and drug resistance profile of clinical Moraxella (M.) catarrhalis, M. osloensis and M. lacunata isolates ...  Read More

Pharmaceutical sciences
Ipragliflozin protect from acute pulmonary injury induced by endotoxemia in mouse model via NF-KB pathway

Noor Adnan Najm; Ekhlas Sabah Hassan

Articles in Press, Accepted Manuscript, Available Online from 24 February 2024

https://doi.org/10.22034/hbb.2024.441674.1139

Abstract
  Sepsis is now more commonly regarded as an uncontrolled inflammatory and immune response throughout the body, triggered by microbial invasion and resulting in high mortality rate from organ damage. This study aimed to demonstrate the protective impact of ipragliflozin on lung damage induced in mice by ...  Read More