Health Biotechnology and Biopharma  


Health Biotechnology and Biopharma (HBB, ISSN: 2538-4414) is a quarterly peer-reviewed journal which promotes latest research which emphasizes on all areas of health biotechnology and biopharma. It is an open access, peer-reviewed and online scientific journal. The aim of this journal is to provide a platform for researchers to promote innovative research. This journal consists of the following sections:

• BioPharm Hypothesis

• Original Research/ Review Article

• Short Communication/ Opinion/ Letter

In the field of pharmaceutical, biological, medicinal and chemical sciences. Bio/Pharm Hypothesis provides novel and innovative ideas in biopharmaceutics, opening the field to radical hypothesis based on non-experimental and experimental research. We assign all articles to Digital Object Identifier (DOI ) of mEDRA. Please submit your manuscript online. There is a processing fee per each article accepted. Similarities of the received manuscripts have been checked by iThenticate to evaluate plagiarism.

Biological sciences
Polyherbal formulation: An alternative therapeutic approach to treat diabetic foot ulcer

Debasmita Dubey; Shakti Rath; Rajesh Kumar Meher; Siba Prasad Dalai; Jayant Kumar Dash; Santosh Kumar Swain

Volume 6, Issue 4 , March 2023, Pages 1-13

  Diabetic Foot Ulcers (DFUs) are a common complication of poorly controlled diabetes and often become infected, termed diabetic foot infection. Despite using several multidisciplinary techniques, no significant cure is still achievable. So, it needs an alternative therapeutic approach to treat diabetic ...  Read More

Medicinal sciences
Evaluation of the pattern of COVID-19 infection in hospital staff in Iran

Ali Dehghani Ahmadabad; Zohreh AkhoundiMeybodi; Ehsan Rezaeinejad

Volume 6, Issue 4 , March 2023, Pages 14-24

  Health-care workers are one of the most at-risk groups in Covid-19 pandemic. The aim of this study was to investigate the pattern of Covid-19 among hospital employees. Among the participants there were 58 % nurses, 12 % physicians, 26 % other wards paraclinical and 4 % service personnel. ...  Read More

Pharmaceutical sciences
Experimental studies and artificial neural networks (ANN) modeling of asparaginase partitioning in aqueous two-phase systems: Polyethylene glycol and inorganic salts

Mohsen Mesbahi-Nowrouzi; Soroush Sardari

Volume 6, Issue 4 , March 2023, Pages 25-42

  This article studied applicabilities of Artificial Neural Networks (ANN), aiming at partitioning of Asparaginase (ASP). The first step investigated the partitioning of ASP using ATPS, consisting of polyethylene glycol and different inorganic salts. The studies of ASP partition were conducted ...  Read More

Medicinal sciences
Stem cells used in infectious diseases like pneumonia, respiratory infections and Covid-19: A study based on doctor’s opinion

Swati Chaudhary; Supriti Agrawal

Volume 6, Issue 4 , March 2023, Pages 43-55

  Worldwide, infectious diseases have contributed significantly to morbidity and mortality; among the leading causes of death are pneumonia, respiratory infections and Covid-19. Stem cell therapy will be used to treat virus-infected patients in an effective and safe manner. A crosssectional ...  Read More

Biological sciences
Induction and evaluation of influenza cell-mediated immune responses by HA2 subunit and bio adjuvant as a gene vaccine candidate

Sina Soleimani; Mohammadreza Ghorani

Volume 6, Issue 4 , March 2023, Pages 56-66

  The stalk domain of influenza as Hemagglutinin 2 (HA2) is a conserved unit of HA and is a candidate for a vaccine construct. We designed HA2/Mx (Myxovirus Resistance) as bio adjuvant construct for vaccine candidates. After immunization of Razi Balb/c mice in DNA/prime/boost strategy, for determination ...  Read More

Determination of CAPN11 and UBQLN3 gene expression in men with Non-Obstructive Azoospermia

Masoud Salehipour; Masoumeh Karimi

Volume 6, Issue 4 , March 2023, Pages 67-80

  Genetic disorders play an important role in male infertility, especially in Non-Obstructive Azoospermia (NOA). Many studies have been performed on the expression profiles of gonadal genes in order to accurately identify the genes involved in impaired spermatogenesis. In the current study, testicular ...  Read More

One pot, green synthesis and biological evaluation of some isatin-based thiocarbohydrazones derivatives

Seyyed Mohammad Shahcheragh; Azizollah Habibi; Masoomeh Shirzad; Yekta Farahani; Soroush Sardari

Volume 6, Issue 4 , March 2023, Pages 81-97

  In the present study, a one-pot, green and three-component route for synthesis of Thiocarbohydrazone (TCS) derivatives is described. This reaction was performed in choline chloride/urea (1:2) as Deep Eutectic Solvent (DES). The structures were characterized by FTIR, 1H NMR, 13C NMR spectra and elemental ...  Read More

Medicinal sciences
Best insights on target molecules for drug design of nCOVID-19 based on pharmacological and peptide-based therapeutics

Seyed Hossein Shahcheraghi; Venant Tchokonte-Nana; Jamshid Ayatollahi; Marzieh Lotfi; Mahdie Hamidfar; Benjamin Longo-Mbenza

Volume 6, Issue 1 , June 2022, , Pages 62-81

  Coronavirus is a non-segmented virus related to Coronaviridae family with an envelope and RNA that has a huge positive-sense single-stranded genome. The causative agent of COVID-19, severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2) first appeared in China in 2019. The role of these viruses ...  Read More

Pharmaceutical sciences
DNA damage protection by fatty acid rich fractions from Andrographis Paniculata Nees (AP): An in vitro study

Pravin D Badhe; Ashwini Badhe; Kajal Nadaf; Srushti Deshmukh; Kishor Otari

Volume 5, Issue 4 , March 2022, , Pages 55-85

  As antioxidants prevent free radical caused DNA damage, they lower the risk of developing chronic diseases. The present study evaluated the impact of fatty acid-rich fractions of Andrographis Paniculata Nees (AP) on free radical-induced DNA damage. We prepared fatty acid-rich fractions with dried AP ...  Read More

New insights into the effects of hydroxychloroquine in COVID-19
Volume 5, Issue 2 , September 2021, , Pages 1-6

  In late 2019 until 2021, the novel coronavirus disease (COVID-19) has become pandemic. This disease is related to severe inflammatory symptoms of the respiratory epithelial cells and the dysfunction of several organs. One of the suggested drugs to reduce the inflammation caused by COVID-19 is hydroxychloroquine. ...  Read More

Association of non-synonymous +326 A>T and synonymous +258 G>A polymorphisms of omentin-1 gene (ITLN-1) among type 2 diabetes patients of Pakistan
Volume 5, Issue 2 , September 2021, , Pages 46-60

  Omentin is an adipocytokine that has anti-diabetic property. Genetic variations in ITLN-1 may affect blood glucose level by inactivating Akt/PKB signaling pathway. The aim of this study was to evaluate the association between ITLN-1 gene non-synonymous +326 A>T and synonymous +258 G>A polymorphisms ...  Read More

The rate of smoking and drug addiction among patients with COVID-19 specially based on sex genetic factor
Volume 5, Issue 2 , September 2021, , Pages 26-33

  The aim of this study was to determine the extent of tobacco and drug addiction to opium, methamphetamine and heroin in hospitalized patients due to COVID-19. In this cross-sectional descriptive study, the rate of smoking and drug addiction among COVID-19 patients admitted to Shahid Sadoughi hospital ...  Read More

Revealing metabolic performance of chinese hamster ovary cell capable of producing erythropoietin by in silico analysis
Articles in Press, Accepted Manuscript, Available Online from 18 February 2023

  Erythropoietin (EPO) is one of the most important hormones in the human body that plays a critical role in preventing cellular damage caused by hypoxia. Due to its effective pharmaceutical performance, recombinant human EPO (rhEPO) is often produced by Chinese Hamster Ovary (CHO) cells as host cells ...  Read More

Medicinal sciences
Daily Consumption of Ambon Banana (Musa paradisiaca var. Sapientum) Improve Cardiometabolic Indicators and Reduce Plasma MDA Levels in Adult Male with Central Obesity

Khairun Nisa; Dewi Nur Fiana; Liana Sidharti

Articles in Press, Accepted Manuscript, Available Online from 27 February 2023

  This study aimed to determine the effect of Ambon banana fruit consumption on plasma MDA levels and other cardiometabolic indicators in adult men with central obesity. A total of 30 volunteers were involved. The volunteers ask to take 250 grams of Ambon banana for breakfast for 28 days. The volunteers ...  Read More

Biological sciences
The Golden Doses of Anti CD3/CD28 Microbeads Plus IL-15 Promote Expansion of Specific T Cells in Human Cytomegalovirus Adaptive Immunotherapy

Arsalan Jalili; Nasser Aghdami; Abbas Hajifathali; Maryam Sayahinouri

Articles in Press, Accepted Manuscript, Available Online from 14 March 2023

  Background: There are various mechanisms are being developed to expand Virus specific T lymphocytes. In this study, the use of anti-CD3/CD28 magnetic microbeads and IL-15 in the culture of T lymphocytes in vitro has a significant role in the proliferation and cytotoxicity of these cells. Materials and ...  Read More

Medicinal sciences
The comparison and analysis among clinical studies of tissue engineering in knee cartilage defect

Ria Andreinie; Jeanne Adiwinata Adiwinata Pawitan

Articles in Press, Accepted Manuscript, Available Online from 24 April 2023

  Treatment of cartilage damage is not satisfactory mainly due to cartilage nature that is avascular, so that its nutrition only depends on the diffusion process, which does not support regeneration. One of the new approaches for regeneration of injured cartilage that have a future is tissue engineering. ...  Read More

Pharmaceutical sciences
Investigating the Protective Effect of the Methanolic Extract of Salvia multicaulis on Renal Ischemia-reperfusion Injuries in Rats

Foroogh Mirzania; Iraj Salimikia; Javad Ghasemian-Yadegari; Javid Aalaei; Mohammad Amin Ghobadi; Majid Taheri Demneh; Alireza Nazarzadeh

Articles in Press, Accepted Manuscript, Available Online from 06 May 2023

  In this research the protective effects of the methanolic extract of S. multicaulis was evaluated in renal ischaemia-reperfusion injuries in rats. 42 male rats were divided into 6 groups. In the treatment groups 1-3, before causing ischemia in the kidneys, rats received 50, 100, and 150 mg/kg/day doses ...  Read More

Medicinal sciences
Determining the characteristics of cerebral metastasis from breast cancer

Reza Nafisi Moghadam; Mojtaba Jokar; Shima sadat Dehghanpour farashah; Alirezaa Zolfagharii

Articles in Press, Accepted Manuscript, Available Online from 08 May 2023

  Breast cancer is the most malignancy in women. The aim of this study was to evaluate determining the characteristics of cerebral metastasis from breast cancer. This cross sectional study was conducted on patients with cerebral metastasis from breast cancer in Shahid Sadoughi hospital from 2014 to 2020 ...  Read More