Health Biotechnology and Biopharma  

 

Health Biotechnology and Biopharma (HBB, ISSN: 2538-4414) is a quarterly peer-reviewed journal which promotes latest research which emphasizes on all areas of health biotechnology and biopharma. It is an open access, peer-reviewed and online scientific journal. The aim of this journal is to provide a platform for researchers to promote innovative research. This journal consists of the following sections:

• BioPharm Hypothesis

• Original Research/ Review Article

• Short Communication/ Opinion/ Letter

In the field of pharmaceutical, biological, medicinal and chemical sciences. Bio/Pharm Hypothesis provides novel and innovative ideas in biopharmaceutics, opening the field to radical hypothesis based on non-experimental and experimental research. We assign all articles to Digital Object Identifier (DOI ) of mEDRA. Please submit your manuscript online. There is a processing fee per each article accepted. Similarities of the received manuscripts have been checked by iThenticate to evaluate plagiarism.

Medicinal sciences
An overview of miRNAs role in neurofibromatosis type 2

Nahid Rezaie; Teymoor Khosravi; Akram Vahidi; Morteza Oladnabi

Volume 7, Issue 2 , September 2023, Pages 1-17

https://doi.org/10.22034/HBB.2023.14

Abstract
  Neurofibromatosis type 2 (NF2) is an autosomal dominant genetic condition that causes tumorigenicity of bilateral vestibular schwannomas. microRNAs (miRNA) are 22-25 nucleotides single-stranded class of non-coding RNAs that play an essential role in mRNA regulation, mostly negatively, in many human diseases, ...  Read More

Biological sciences
A review of similarity of KLF2, MSX1 and SOX9 genes expression in zebrafish and human

Mehdi Ahmadifar; Reihaneh Balali; sadaf reihani; zeinab jarban

Volume 7, Issue 2 , September 2023, Pages 18-34

https://doi.org/10.22034/HBB.2023.15

Abstract
  In recent studies, the focus on zebrafish, as a suitable laboratory model for studying vertebrate gene function, has increased dramatically. We evaluated the similarity between the three genes KLF2, MSX1 and SOX9 in humans and zebrafish. The KLF2 gene plays a role in heart and immunity of humans and ...  Read More

Biological sciences
Preconditioning with IFN-γ and LPS improves the immunomodulatory potential of bone marrow-derived clonal mesenchymal stem cells

Mehdi Soleymani-Goloujeh; Faezeh Shekari; Seyedeh-Nafiseh Hassani; Ensiyeh Hajizadeh-Saffar

Volume 7, Issue 2 , September 2023, Pages 35-51

https://doi.org/10.22034/HBB.2023.16

Abstract
  Mesenchymal Stem Cells (MSCs) are one of the promising cellular therapies for immune-related diseases. Preconditioning of MSCs increases their efficacy and overcomes several hurdles in MSC-based therapies. It reduces tissue inflammation and improves cell survival, consequently enhancing therapeutic outcomes. ...  Read More

Pharmaceutical sciences
Thermal stability and pH of antioxidant activity of ethanol extract of Ciplukan herbs (Physalis angulata Linn) along with determination of pKa

Yoga Windhu Wardhana; Bayu Indradi; Ade Zuhrotun; Rini Hendriani; Winda Agnestia Maranna Saragih; Savira Ekawardhani; Hesti Lina Wiraswasti; Enny Rohmawaty; Sumartini Dewi

Volume 7, Issue 2 , September 2023, Pages 52-65

https://doi.org/10.22034/HBB.2023.17

Abstract
  In this study, thermal stability and pH for the antioxidant activity of the ethanol extract of ciplukan (Physalis angulata Linn) herbs had been studied. Among the antioxidant activity methods, the use of DPPH (2,2-diphenyl-1-picrylhydrazyl) reagent is simple and easy to use. The thermal effect was observed ...  Read More

Biological sciences
Genotyping of KELL blood group in multiethnic populations of Quetta, Pakistan

Asifa Bibi; Nabeela Tariq; Hamida Ali; Zil-e-Huma Butt; Tasleem Kausar; Maqsood Maryam

Volume 7, Issue 2 , September 2023, Pages 66-81

https://doi.org/10.22034/HBB.2023.18

Abstract
  KEL1 (Kell or K) is highly immunogenic with limited distribution while KEL2 (Cellano or k) antigen is more prevalent. The antigenic diversity in the Kell gene is a result of Single Nucleotide Polymorphisms (SNPs). Blood samples of 160 males and females from each ethnic group with no age restrictions ...  Read More

Pharmaceutical sciences
Increased risk of cerebral dysfunction by high-fructose diet consumption: A 90 -day study in female rats

Roya Mirzaei; Sepideh Arbabi Bidgoli; Roya Khosrokhavar; Shahram Shoeibi; Hamidreza Ahmadi Ashtiani

Volume 7, Issue 2 , September 2023, Pages 82-100

https://doi.org/10.22034/HBB.2023.19

Abstract
  Our study was designed to evaluate any changes in the liver, kidney, and brain tissues of female wistar rats to a fructose-enriched diet. Rats were divided into three groups (n=5/group). Monitoring of daily water-food consumption and clinical changes continued for 90 days. Afterward, the alteration of ...  Read More

Medicinal sciences
Best insights on target molecules for drug design of nCOVID-19 based on pharmacological and peptide-based therapeutics

Seyed Hossein Shahcheraghi; Venant Tchokonte-Nana; Jamshid Ayatollahi; Marzieh Lotfi; Mahdie Hamidfar; Benjamin Longo-Mbenza

Volume 6, Issue 1 , June 2022, , Pages 62-81

https://doi.org/10.22034/HBB.2022.12

Abstract
  Coronavirus is a non-segmented virus related to Coronaviridae family with an envelope and RNA that has a huge positive-sense single-stranded genome. The causative agent of COVID-19, severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2) first appeared in China in 2019. The role of these viruses ...  Read More

Pharmaceutical sciences
DNA damage protection by fatty acid rich fractions from Andrographis Paniculata Nees (AP): An in vitro study

Pravin D Badhe; Ashwini Badhe; Kajal Nadaf; Srushti Deshmukh; Kishor Otari

Volume 5, Issue 4 , March 2022, , Pages 55-85

https://doi.org/10.22034/HBB.2022.04

Abstract
  As antioxidants prevent free radical caused DNA damage, they lower the risk of developing chronic diseases. The present study evaluated the impact of fatty acid-rich fractions of Andrographis Paniculata Nees (AP) on free radical-induced DNA damage. We prepared fatty acid-rich fractions with dried AP ...  Read More

Hypothesis of a potential antiviral drug

Kevin Ricardo Espinosa

Volume 6, Issue 3 , December 2022, , Pages 1-10

https://doi.org/10.22034/HBB.2022.19

Abstract
  The approval of mRNA vaccine technique against COVID-19 opens a door to research and the creation of new drugs against different infectious pathologies or even cancer, since for several diseases the therapeutic options are limited, and different viral diseases are treated only symptomatically. For these ...  Read More

New insights into the effects of hydroxychloroquine in COVID-19
Volume 5, Issue 2 , September 2021, , Pages 1-6

https://doi.org/10.22034/HBB.2021.13

Abstract
  In late 2019 until 2021, the novel coronavirus disease (COVID-19) has become pandemic. This disease is related to severe inflammatory symptoms of the respiratory epithelial cells and the dysfunction of several organs. One of the suggested drugs to reduce the inflammation caused by COVID-19 is hydroxychloroquine. ...  Read More

Association of non-synonymous +326 A>T and synonymous +258 G>A polymorphisms of omentin-1 gene (ITLN-1) among type 2 diabetes patients of Pakistan
Volume 5, Issue 2 , September 2021, , Pages 46-60

https://doi.org/10.22034/HBB.2021.18

Abstract
  Omentin is an adipocytokine that has anti-diabetic property. Genetic variations in ITLN-1 may affect blood glucose level by inactivating Akt/PKB signaling pathway. The aim of this study was to evaluate the association between ITLN-1 gene non-synonymous +326 A>T and synonymous +258 G>A polymorphisms ...  Read More

Pharmaceutical sciences
A New Frontier: Unveiling the Possibility of Targeting Intracellular Antigens with Nucleic Acid Aptamers

Zahra Salimi; Mohammad Ahmadyousefi

Articles in Press, Accepted Manuscript, Available Online from 20 September 2023

https://doi.org/10.22034/hbb.2023.409781.1105

Abstract
  Proven RNA-based medications have elevated the demand for targeted nucleic acid-based agents. In this context, nucleic acid aptamers represent an appropriate class of molecules. They are single-stranded nucleic acid molecules that bind to a target molecule with high affinity and specificity. Aptamers ...  Read More

Pharmaceutical sciences
Introducing an innovative algorithm based on the abilities of the human perception system towards profiling similarity search of drugs and drug-like compounds: Fluoxetine as an example

Soroush Sardari; Setareh Ghavami; Ghazaleh Ghavami; Hassan Toozandehjani

Articles in Press, Accepted Manuscript, Available Online from 20 September 2023

https://doi.org/10.22034/hbb.2023.387747.1076

Abstract
  Small molecule similarity search as one of the ligand-based virtual screening strategies play a critical role in drug discovery procedures. The current research has been finalized based on the employing interdisciplinary aspects in addition to utilizing skills of cheminformatics in addition to psychosomatic ...  Read More

Biological sciences
Exploring Bacillus subtilis Isolated from Soil as a Promising Alternative for L-Asparaginase Enzyme Production

Seyed Mohammad Haji Mirghasemi; Hamid Reza Pordeli; Leila Fozouni; Mina Komshikamar; fatemeh komshikamar; Mansoor Rubin

Articles in Press, Accepted Manuscript, Available Online from 23 September 2023

https://doi.org/10.22034/hbb.2023.409710.1103

Abstract
  A high L-ASNase enzyme production by Bacillus subtilis can hold significant promise as an alternative bacterial source to meet anti-cancer therapies demand. In this study, eight bacterial isolates were obtained from the 35 soil samples of Golestan province, Iran. Samples were collected from different ...  Read More