Health Biotechnology and Biopharma  


Health Biotechnology and Biopharma (HBB, ISSN: 2538-4414) is a quarterly peer-reviewed journal which promotes latest research which emphasizes on all areas of health biotechnology and biopharma. It is an open access, peer-reviewed and online scientific journal. The aim of this journal is to provide a platform for researchers to promote innovative research. This journal consists of the following sections:

• BioPharm Hypothesis

• Original Research/ Review Article

• Short Communication/ Opinion/ Letter

In the field of pharmaceutical, biological, medicinal and chemical sciences. Bio/Pharm Hypothesis provides novel and innovative ideas in biopharmaceutics, opening the field to radical hypothesis based on non-experimental and experimental research. We assign all articles to Digital Object Identifier (DOI ) of mEDRA. Please submit your manuscript online.

Carbon quantum dots may interfere with colorectal cancer treatment through affecting on glutamine metabolism

Mohadeseh Nemati; Fahima Danesh Pouya; Fateme Zarein; Mahdieh Nemati; Yousef Rasmi; Jafar Rezaie; Tooba Hallaj

Volume 6, Issue 2 , September 2022, Pages 1-5

  Cancer cells are metabolically different from normal cells, including the Warburg effect and uses glutamine to fill the Tricarboxylic Acid (TCA) cycle. It was demonstrated inhibiting glutamine metabolism prevents tumor growth. The mammalian Target of Rapamycin (mTOR) is one of the signaling pathways ...  Read More

Medicinal sciences
Investigating cellular and molecular factors effective in leukemia and analyzing the immune system

Nastaran Sahraei; Mina Mobin Rahni; Mehdi Ahmadifar

Volume 6, Issue 2 , September 2022, Pages 6-42

  Leukemia as one of the common cancers is still studied and needs improvement in diagnosis and treatment. In this study, we examined the activity of hematopoietic stem cells, which can be a precursor to leukemia. Hematopoietic cancer cells, by affecting the bone marrow, preserve the source of stem cells ...  Read More

Evaluation of ESR, CRP, LDH, CPK, D-Dimer, BS and FBS levels in hospitalized COVID-19 patients with mucormycosis

Seyed Hossein Shahcheraghi; Mahdie Hamidfar; Faezehsadat Heidari; Sajjad Shahmohammadi; Zohre Akhondimeybodi; Tahere Fallah; Yegane Aliakbarzade Yazdani

Volume 6, Issue 2 , September 2022, Pages 43-51

  Mucormycosis in COVID-19 patients of severe type has been reported. This study was intended to evaluate ESR, CRP, LDH, CPK, D-Dimer, BS and FBS levels in COVID-19 patients with mucormycosis. Information was recorded including gender, age, hospitalization and recovery. The laboratory parameters contained ...  Read More

Comparison of surgical site infection using active and passive surveillance methods in two months

Zohreh AkhoundiMeybodi; Mohammad Sharifyazdi; Reyhane Shaterian; bijan jafarnia; kazem ansari

Volume 6, Issue 2 , September 2022, Pages 52-63

  The aim of this study was to compare active and passive surveillance methods. This descriptive cross-sectional study was conducted on 296 patients who were admitted to Shahid Sadoughi hospital in Yazd from 2018 to 2020. Surveillance for signs of Surgical Site Infection (SSI) was done using passive (via ...  Read More

Antibiotic resistance pattern and frequency of SHV, CTX, TEM, and OXA resistance gene among salmonella serotypes

Maryam Naderi Mezajin; Mahdi Fatemizadeh; Zahra Rostami; Pejvak Khaki; Masoomeh Shirzad; Fatemeh Noorbakhsh

Volume 6, Issue 2 , September 2022, Pages 64-77

  The aim of this study was to investigate the antibiotic resistance and identification of strains producing broad-spectrum beta-lactamases salmonella strains. The 70 different strains of salmonella were studied that gentamicin, ciprofloxacin, ofloxacin, imipenem, and enrofloxacin were susceptible. The ...  Read More

Biological sciences
Ectodermal Dysplasia patients susceptible to COVID-19

Saeed Dorgaleleh; Karim naghipoor; Morteza Oladnabi

Volume 6, Issue 2 , September 2022, Pages 78-80

  Ectodermal dysplasia (ED) is a rare heterogeneous disorder. Defects in the development of the ectoderm cause symptoms in tissues derived from the ectoderm layer such as skin, nails and hair. One of the genes involved in ED is Nuclear Factor Kappa-B (NF-κB) that mutation in this gene causes immunodeficiency. ...  Read More

Medicinal sciences
Best insights on target molecules for drug design of nCOVID-19 based on pharmacological and peptide-based therapeutics

Seyed Hossein Shahcheraghi; Venant Tchokonte-Nana; Jamshid Ayatollahi; Marzieh Lotfi; Mahdie Hamidfar; Benjamin Longo-Mbenza

Volume 6, Issue 1 , June 2022, , Pages 62-81

  Coronavirus is a non-segmented virus related to Coronaviridae family with an envelope and RNA that has a huge positive-sense single-stranded genome. The causative agent of COVID-19, severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2) first appeared in China in 2019. The role of these viruses ...  Read More

Pharmaceutical sciences
DNA damage protection by fatty acid rich fractions from Andrographis Paniculata Nees (AP): An in vitro study

Pravin D Badhe; Ashwini Badhe; Kajal Nadaf; Srushti Deshmukh; Kishor Otari

Volume 5, Issue 4 , March 2022, , Pages 55-85

  As antioxidants prevent free radical caused DNA damage, they lower the risk of developing chronic diseases. The present study evaluated the impact of fatty acid-rich fractions of Andrographis Paniculata Nees (AP) on free radical-induced DNA damage. We prepared fatty acid-rich fractions with dried AP ...  Read More

New insights into the effects of hydroxychloroquine in COVID-19
Volume 5, Issue 2 , September 2021, , Pages 1-6

  In late 2019 until 2021, the novel coronavirus disease (COVID-19) has become pandemic. This disease is related to severe inflammatory symptoms of the respiratory epithelial cells and the dysfunction of several organs. One of the suggested drugs to reduce the inflammation caused by COVID-19 is hydroxychloroquine. ...  Read More

Association of non-synonymous +326 A>T and synonymous +258 G>A polymorphisms of omentin-1 gene (ITLN-1) among type 2 diabetes patients of Pakistan
Volume 5, Issue 2 , September 2021, , Pages 46-60

  Omentin is an adipocytokine that has anti-diabetic property. Genetic variations in ITLN-1 may affect blood glucose level by inactivating Akt/PKB signaling pathway. The aim of this study was to evaluate the association between ITLN-1 gene non-synonymous +326 A>T and synonymous +258 G>A polymorphisms ...  Read More

The rate of smoking and drug addiction among patients with COVID-19 specially based on sex genetic factor
Volume 5, Issue 2 , September 2021, , Pages 26-33

  The aim of this study was to determine the extent of tobacco and drug addiction to opium, methamphetamine and heroin in hospitalized patients due to COVID-19. In this cross-sectional descriptive study, the rate of smoking and drug addiction among COVID-19 patients admitted to Shahid Sadoughi hospital ...  Read More

Hypothesis of a potential antiviral drug

Kevin Ricardo Espinosa

Articles in Press, Accepted Manuscript, Available Online from 02 October 2022

  The approval of the mRNA vaccine technique against COVID-19 opens a door to research and the creation of new drugs against different infectious pathologies or even cancer, since for several diseases the therapeutic options are limited, and different viral diseases They are treated only symptomatically. ...  Read More

Effect of Ajwa Date (Phoenix dactilyfera L.) Extract in Aspirin Induced Peptic Ulcer Model

Hendri Busman; Winda Trijayanthi Utama; Rizki Hanriko; Jason Mikail Amper; Indriyani Indriyani

Articles in Press, Accepted Manuscript, Available Online from 02 October 2022

  Dates have been used to ameliorate various gastrointestinal diseases. This study aimed to evaluate the gastroprotective effect of ajwa dates extract on rats induced by aspirin. Rats were divided into five groups using a completely randomized design. Group 1 received only 300mg/kg BW aspirin. Group 2 ...  Read More

Formulation development of Ezetimibe by using Soluplus and Co- Processed Acacia: Tragacanth with Design Expert

TarakaRamarao Ch; Ravali Jami

Articles in Press, Accepted Manuscript, Available Online from 02 October 2022

  Ezetimibe is a an antihyperlipidemic drug that lowers cholesterol levels.The purpose of this study was to compare different amounts of solid dispersions and formulations using various carriers in order to improve the dissolution. The Design Expert software was used to perform analysis of variance (ANOVA), ...  Read More

Advantages of selected natural and synthetic scaffolds in vascular tissue engineering

Helsy Junaidi; Jeanne Adiwinata Pawitan

Articles in Press, Accepted Manuscript, Available Online from 02 October 2022

  The development of tissue engineering provides various opportunities to engineer various tissues/organs, including vascular tissue engineering. Scaffold plays an essential role in vascular tissue engineering. The selection of biomaterials used as scaffolds will determine the success of vascular tissue ...  Read More

Medicinal sciences
Isolation of MDR Providencia stuartii from tracheal aspirates of two hospitalized patients

Niloofar Rezaie; Shadi Agghamohammad; Mahdi Rohani; Abdolreza Javadi; Farzad Badmasti; Armaghan Soltani Shirazi

Articles in Press, Accepted Manuscript, Available Online from 09 October 2022

  Background: The emergence of nosocomial infection due to Multi Drug Resistant (MDR) bacteria is a challenge to infection control. Methods: This study was presented two Providencia species from two hospitalized patients admitted in Imam Hussein hospital, Iran. Biochemical and molecular tests were performed ...  Read More

Biological sciences
Whole Exome Sequencing Reveals the First c.7456C>T p.Arg2486X Mutation in ATM gene in Iranian Population

Saeed Dorgaleleh; Karim Naghipoor; Teymoor Khosravi; Amin Tadayoni Nia; Elham Sheikhi Ghayur; Hamayon abdul Aziz; Morteza Oladnabi

Articles in Press, Accepted Manuscript, Available Online from 24 October 2022

  Ataxia-telangiectasia (A-T) is a rare neurodegenerative disorder that presents with cerebral ataxia and oculocutaneous telangiectasia. Mutations in Ataxia-Telangiectasia Mutated (ATM) gene are prominently responsible for the condition. ATM gene encodes a serine/threonine protein kinase, a crucial component ...  Read More