Health Biotechnology and Biopharma  


Health Biotechnology and Biopharma (HBB, ISSN: 2538-4414) is a quarterly peer-reviewed journal which promotes latest research which emphasizes on all areas of health biotechnology and biopharma. It is an open access, peer-reviewed and online scientific journal. The aim of this journal is to provide a platform for researchers to promote innovative research. This journal consists of the following sections:

• BioPharm Hypothesis

• Original Research/ Review Article

• Short Communication/ Opinion/ Letter

In the field of pharmaceutical, biological, medicinal and chemical sciences. Bio/Pharm Hypothesis provides novel and innovative ideas in biopharmaceutics, opening the field to radical hypothesis based on non-experimental and experimental research. We assign all articles to Digital Object Identifier (DOI ) of mEDRA. Please submit your manuscript online. There is a processing fee per each article accepted. Similarities of the received manuscripts have been checked by iThenticate to evaluate plagiarism.

Hypothesis of a potential antiviral drug

Kevin Ricardo Espinosa

Volume 6, Issue 3 , December 2022, Pages 1-10

  The approval of mRNA vaccine technique against COVID-19 opens a door to research and the creation of new drugs against different infectious pathologies or even cancer, since for several diseases the therapeutic options are limited, and different viral diseases are treated only symptomatically. For these ...  Read More

Advantages of selected natural and synthetic materials as scaffolds in vascular tissue engineering

Helsy Junaidi; Jeanne Adiwinata Pawitan

Volume 6, Issue 3 , December 2022, Pages 11-22

  The development of tissue engineering provides various opportunities to vascular tissue engineering. Scaffold plays an essential role in vascular tissue engineering. The selection of biomaterials used as scaffolds will determine the success of vascular tissue engineering. The structure of vascular system, ...  Read More

Effect of Ajwa Date (Phoenix dactilyfera L.) extract in aspirin induced peptic ulcer model

Hendri Busman; Winda Trijayanthi Utama; Rizki Hanriko; Jason Mikail Amper; Indriyani Indriyani

Volume 6, Issue 3 , December 2022, Pages 23-32

  Dates have been used to ameliorate various gastrointestinal diseases. This study aimed to evaluate the gastroprotective effect of ajwa dates extract on rats induced by aspirin. Rats were divided into five groups using a completely randomized design. Group 1 received only 300 mg/kg BW aspirin. Group 2 ...  Read More

Formulation development of Ezetimibe by using Soluplus and Co- Processed Acacia: tragacanth with Design Expert

TarakaRamarao Ch; Ravali Jami

Volume 6, Issue 3 , December 2022, Pages 33-56

  Ezetimibe is an antihyperlipidemic drug that lowers cholesterol levels. The purpose of this study was to compare different amounts of solid dispersions and formulations using various carriers in order to improve the dissolution. The Design Expert software was used to perform Analysis of Variance (ANOVA), ...  Read More

Biological sciences
Whole exome sequencing reveals the first c.7456C>T p.Arg2486X mutation in ATM gene in Iranian population

Saeed Dorgaleleh; Karim Naghipoor; Teymoor Khosravi; Amin Tadayoni Nia; Elham Sheikhi Ghayur; Hamayon abdul Aziz; Morteza Oladnabi

Volume 6, Issue 3 , December 2022, Pages 57-72

  Mutations in Ataxia-Telangiectasia Mutated (ATM) gene are prominently responsible for the condition. ATM gene encodes a serine/threonine protein kinase, a crucial component in DNA repair systems. Whole exome sequencing was performed on a nine year old male subject with clinical features of A-T. Alpha ...  Read More

Medicinal sciences
Isolation of MDR Providencia stuartii from tracheal aspirates of two hospitalized patients

Niloofar Rezaie; Shadi Agghamohammad; Mahdi Rohani; Abdolreza Javadi; Farzad Badmasti; Armaghan Soltani Shirazi

Volume 6, Issue 3 , December 2022, Pages 73-79

  The emergence of nosocomial infection due to Multi-Drug Resistant (MDR) bacteria is a challenge to infection control. This study presented two Providencia species from two hospitalized patients admitted to Imam Hussein hospital in Iran. Biochemical and molecular tests were performed for the identification ...  Read More

Medicinal sciences
Best insights on target molecules for drug design of nCOVID-19 based on pharmacological and peptide-based therapeutics

Seyed Hossein Shahcheraghi; Venant Tchokonte-Nana; Jamshid Ayatollahi; Marzieh Lotfi; Mahdie Hamidfar; Benjamin Longo-Mbenza

Volume 6, Issue 1 , June 2022, , Pages 62-81

  Coronavirus is a non-segmented virus related to Coronaviridae family with an envelope and RNA that has a huge positive-sense single-stranded genome. The causative agent of COVID-19, severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2) first appeared in China in 2019. The role of these viruses ...  Read More

Pharmaceutical sciences
DNA damage protection by fatty acid rich fractions from Andrographis Paniculata Nees (AP): An in vitro study

Pravin D Badhe; Ashwini Badhe; Kajal Nadaf; Srushti Deshmukh; Kishor Otari

Volume 5, Issue 4 , March 2022, , Pages 55-85

  As antioxidants prevent free radical caused DNA damage, they lower the risk of developing chronic diseases. The present study evaluated the impact of fatty acid-rich fractions of Andrographis Paniculata Nees (AP) on free radical-induced DNA damage. We prepared fatty acid-rich fractions with dried AP ...  Read More

New insights into the effects of hydroxychloroquine in COVID-19
Volume 5, Issue 2 , September 2021, , Pages 1-6

  In late 2019 until 2021, the novel coronavirus disease (COVID-19) has become pandemic. This disease is related to severe inflammatory symptoms of the respiratory epithelial cells and the dysfunction of several organs. One of the suggested drugs to reduce the inflammation caused by COVID-19 is hydroxychloroquine. ...  Read More

Association of non-synonymous +326 A>T and synonymous +258 G>A polymorphisms of omentin-1 gene (ITLN-1) among type 2 diabetes patients of Pakistan
Volume 5, Issue 2 , September 2021, , Pages 46-60

  Omentin is an adipocytokine that has anti-diabetic property. Genetic variations in ITLN-1 may affect blood glucose level by inactivating Akt/PKB signaling pathway. The aim of this study was to evaluate the association between ITLN-1 gene non-synonymous +326 A>T and synonymous +258 G>A polymorphisms ...  Read More

The rate of smoking and drug addiction among patients with COVID-19 specially based on sex genetic factor
Volume 5, Issue 2 , September 2021, , Pages 26-33

  The aim of this study was to determine the extent of tobacco and drug addiction to opium, methamphetamine and heroin in hospitalized patients due to COVID-19. In this cross-sectional descriptive study, the rate of smoking and drug addiction among COVID-19 patients admitted to Shahid Sadoughi hospital ...  Read More

Pharmaceutical sciences
Experimental studies and artificial neural networks (ANN) modeling of asparaginase partitioning in aqueous two-phase systems: Polyethylene glycol and inorganic salts

MOHSEN Mesbahi-Nowrouzi; Soroush Sardari

Articles in Press, Accepted Manuscript, Available Online from 24 December 2022

  This article studies the applicabilities of ATPS and ANN, aiming at partitioning of asparaginase (ASP). The first step investigates the partitioning of ASP using ATPS, consisting of polyethylene glycol and different inorganic salts. The studies of ASP partition were conducted by measuring the amounts ...  Read More

Biological sciences
Polyherbal formulation: An alternative therapeutic approach to treat Diabetic foot ulcer

Debasmita Dubey; Shakti Rath; Rajesh Kumar Meher; Siba Prasad Dalai; Jayant Kumar Dash; Santosh Kumar Swain

Articles in Press, Accepted Manuscript, Available Online from 24 December 2022

  Diabetic foot ulcers (DFUs) are a common complication of poorly controlled diabetes and often become infected, termed diabetic foot infection. Despite using several multidisciplinary techniques, no significant cure is still achievable. So, it needs an alternative therapeutic approach to treat diabetic ...  Read More

Biological sciences
Induction and evaluation of influenza A cell-mediated immune responses by hemagglutinin 2 subunit and bio adjuvant as a DNA-based vaccine candidate

Sina Soleimani; Mohammad reza Ghorani

Articles in Press, Accepted Manuscript, Available Online from 03 January 2023

  The stalk domain of influenza as hemagglutinin 2 (HA2) is a conserved unit of HA and is a candidate for a vaccine construct. We designed HA2/Mx (Myxovirus Resistance) as bio adjuvant construct for vaccine candidates. After immunization of Razi Balb / c mice in DNA/prime/boost strategy, for determination ...  Read More

Medicinal sciences
Evaluation of the pattern of COVID-19 infection in hospital staff in Yazd, Iran: A cross sectional study

Ali Dehghani Ahmadabad; Zohreh AkhoundiMeybodi; ehsan rezaeinejad; kazem ansari

Articles in Press, Accepted Manuscript, Available Online from 16 January 2023

  Health-care workers are one of the most at-risk groups in Covid-19 pandemic. The aim of this study was to investigate the pattern of Covid-19 among Hospital employees. This study was case control. Study data were analyzed using SPSS software. Among the participants there were 58% nurses, 12% physicians, ...  Read More

Medicinal sciences
Stem Cell Used in Infectious Diseases like pneumonia, respiratory infections and Covid-19: A Study Based on Doctors Opinion

Swati Chaudhary; Supriti Agrawal

Articles in Press, Accepted Manuscript, Available Online from 21 January 2023

  Worldwide, infectious diseases have contributed significantly to morbidity and mortality; among the leading causes of death are pneumonia, respiratory infections and Covid-19. Stem cell therapy will be used to treat virus-infected patients in an effective and safe manner. A cross-sectional questionnaire ...  Read More