Medicinal sciences
The comparison and analysis among clinical studies of tissue engineering in knee cartilage defects

Ria Andreinie; Jeanne Adiwinata Adiwinata Pawitan

Volume 7, Issue 1 , July 2023, Pages 1-21

  Treatment of cartilage damage is not satisfactory mainly due to cartilage nature that is avascular, so that its nutrition only depends on the diffusion process, which does not support regeneration. One of the new approaches for regeneration of injured cartilage that have a future is tissue engineering. ...  Read More

Biological sciences
The golden doses of anti CD3/CD28 microbeads plus IL-15 promote expansion of specific T cells in human cytomegalovirus adaptive immunotherapy

Arsalan Jalili; Nasser Aghdami; Abbas Hajifathali; Maryam Sayahinouri

Volume 7, Issue 1 , July 2023, Pages 22-45

  In this study, the use of anti-CD3/CD28 magnetic microbeads and IL-15 in the culture of T lymphocytes in vitro had a significant role in the proliferation and cytotoxicity of these cells. Peripheral blood mononuclear cells of 6 (Cytomegalovirus) HCMV positive volunteers were harvested, then the pure ...  Read More

Medicinal sciences
Determining characteristics of cerebral metastasis from breast cancer

Reza Nafisi Moghadam; Mojtaba Jokar; Shima sadat Dehghanpour farashah; Alirezaa Zolfagharii

Volume 7, Issue 1 , July 2023, Pages 46-59

  The aim of this study was to evaluate the characteristics of cerebral metastasis from breast cancer. This cross sectional study was conducted on patients with cerebral metastasis from breast cancer in Shahid Sadoughi hospital from 2014 to 2020 and was conducted on 37 patients with mean age 50.83± ...  Read More

Pharmaceutical sciences
Investigating the protective effect of the methanolic extract of Salvia multicaulis on renal ischemia-reperfusion injuries in rats

Foroogh Mirzania; Iraj Salimikia; Javad Ghasemian-Yadegari; Javid Aalaei; Mohammad Amin Ghobadi; Majid Taheri Demneh; Alireza Nazarzadeh

Volume 7, Issue 1 , July 2023, Pages 60-77

  In this research the protective effects of the methanolic extract of S. multicaulis was evaluated in renal ischaemia-reperfusion injuries in rats. 42 male rats were divided into 6 groups. In the treatment groups 1-3, before causing ischemia in the kidneys, rats received 50, 100, and 150 mg/kg/day doses ...  Read More

Medicinal sciences
Daily consumption of Ambon banana (Musa paradisiaca var. sapientum) improve cardiometabolic indicators and reduce plasma MDA levels in adult male with central obesity

Khairun Nisa; Dewi Nur Fiana; Liana Sidharti

Volume 7, Issue 1 , July 2023, Pages 78-89

  This study aimed to determine the effect of Ambon banana fruit consumption on plasma malondialdehyde (MDA) levels and other cardiometabolic indicators in adult men with central obesity. A total of 30 volunteers were involved. The volunteers were examined for their plasma MDA levels and cardiometabolic ...  Read More

Revealing metabolic performance of chinese hamster ovary cell capable of producing erythropoietin by in silico analysis

Samira Beyramy; Soroush Sardari

Volume 7, Issue 1 , July 2023, Pages 90-114

  Erythropoietin (EPO) is one of the most important hormones in the human body, due to its effective pharmaceutical performance, recombinant human EPO (rhEPO) is often produced by Chinese Hamster Ovary (CHO) cells as host cells through recombinant DNA technology on an industrial scale. In this study, the ...  Read More