Document Type : Original Research Article
Authors
- Foroogh Mirzania 1
- Iraj Salimikia 2
- Javad Ghasemian-Yadegari 2
- Javid Aalaei 3
- Mohammad Amin Ghobadi 3
- Majid Taheri Demneh 4
- Alireza Nazarzadeh 3
1 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran; Department of Pharmacognosy, Faculty of Pharmacy, Lorestan University of Medical Sciences, P.O. Box: 6813833946, Khorramabad, Lorestan Province, Iran.
2 Department of Pharmacognosy, Faculty of Pharmacy, Lorestan University of Medical Sciences, P.O. Box: 6813833946, Khorramabad, Lorestan Province, Iran. Tel: +986633120239, fax: +986633120240.
3 Student Research Committee, Faculty of Pharmacy, Lorestan University of Medical Sciences.
4 Student Research Committee, Faculty of Medical, Shahrekord University of Medical Sciences
Abstract
In this research the protective effects of the methanolic extract of S. multicaulis was evaluated in renal ischaemia-reperfusion injuries in rats. 42 male rats were divided into 6 groups. In the treatment groups 1-3, before causing ischemia in the kidneys, rats received 50, 100, and 150 mg/kg/day doses of the extract orally for 20 days, then ischaemia was created. In the evaluation of urea and creatinine factor, rosmarinic acid and extract dose of 150 mg/kg/day had a significant effect in reducing these two factors.
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