Document Type : Original Research Article

Authors

• Foroogh Mirzania ¹
• Iraj Salimikia ²
• Javad Ghasemian-Yadegari ²
• Javid Aalaei ³
• Mohammad Amin Ghobadi ³
• Majid Taheri Demneh ⁴
• Alireza Nazarzadeh ³

¹ Department of Pharmacognosy, Faculty of Pharmacy, Lorestan University of Medical Sciences, P.O. Box: 6813833946, Khorramabad, Lorestan Province, Iran.

² Department of Pharmacognosy, Faculty of Pharmacy, Lorestan University of Medical Sciences, P.O. Box: 6813833946, Khorramabad, Lorestan Province, Iran. Tel: +986633120239, fax: +986633120240.

³ Student Research Committee, Faculty of Pharmacy, Lorestan University of Medical Sciences.

⁴ Student Research Committee, Faculty of Medical, Shahrekord University of Medical Sciences

Abstract

In this research the protective effects of the methanolic extract of S. multicaulis was evaluated in renal ischaemia-reperfusion injuries in rats. 42 male rats were divided into 6 groups. In the treatment groups 1-3, before causing ischemia in the kidneys, rats received 50, 100, and 150 mg/kg/day doses of the extract orally for 20 days, and in the fourth group, 20-days pretreatment with rosmarinic acid solution 0.125 mg/kg/day was administered intraperitoneally in DMSO and normal saline, and then ischaemia was created. In the evaluation of urea and creatinine factor, rosmarinic acid and extract dose of 150 mg/kg/day had a significant effect in reducing these two factors. It is estimated that doses of 100 and 150 mg/kg/day of methanol extract of S. multicaulis are the most effective and useful doses of this plant for renal ischemia reperfusion.

Keywords

• Salvia multicaulis
• rosmarinic acid
• renal ischaemia-reperfusion

Main Subjects

• Pharmaceutical sciences