Document Type : Original Research Article

Authors

• Ani Boghozian ¹
• Ali Choopani ²
• Hamid Reza Shiran ³
• Amirhossein Choopani ⁴
• Nahid Ghaedamini ²

¹ Department of Biochemistry, Payame Noor University, Tehran, Iran

² Amiran Oghyanoos Biotechnology Company, Tehran, Iran

³ Department of Environmental Engineering, School of Environmental, University of Tehran, Iran

⁴ Department of Environmental Science, University of Agricultural Sciences and Natural Resources, Grogan, Iran;

Abstract

The purpose of this study was to investigate the effect of Artemisia Ouchei on the liver enzymes of post -treatment with paracetamol. Artemisia was collected from Kashan area in Iran. The flower Essential Oil of this plant was extracted using a cloner device and the components of it were separated and identified using gas chromatography mass spectrometry. Four groups of animals were used to measure liver factors: 1- control, 2- paracetamol, 3- paracetamol with essential oil, 4- essential oil only. Paracetamol was injected for 3 days and essential oil for 7 days. ALP, AST, ALT were measured 3 days after the last blood transfusion. Essential oil with paracetamol significantly reduced AST and ALT levels and increased ALP level compared to paracetamol alone. Paracetamol and Artemisia Ouchei both caused liver damage by oxidative stress, but their combined use reduced their toxicity.

Keywords

• Artemisia ouchei
• Paracetamol
• Alanine Transferase
• Aspartate Transferase
• Alkaline Phosphatase

Main Subjects

• Medicinal sciences