Document Type : Original Research Article

Authors

• Setareh Ghavami ¹
• Ghazaleh Ghavami ¹
• Hassan Toozandehjani ²
• Soroush Sardari ¹

¹ Drug Design and Bioinformatics Unit, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran 13164, Iran

² Department of Psychology, School of Humanities, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran

Abstract

Small molecule similarity search as one of the ligand-based virtual screening strategies play a critical role in drug discovery procedures. The current research has been finalized based on the employing interdisciplinary aspects in addition to utilizing skills of cheminformatics in addition to psychosomatic facts towards introducing the innovative translator machine system named as TMS-CH for converting small molecule structures to melodic composition and image color combination on the subject of completing inventive pattern and process for chemical structure similarity search. The percentage of true answers for the entire tests among 200 participants confirmed the ability of the proposed TMS-CH system for evaluating the matching level between tested structures. The perception of chemical structures via visual and auditory representations by bio-mimicking human systems during the current investigation can be an efficient strategy to develop findings related to ligand-based similarity search methods.

Keywords

• Virtual screening
• Similarity search
• Pattern recognition
• Drug-like compounds

Main Subjects

• Pharmaceutical sciences