Document Type : Hypothesis

Authors

• Zahra Salimi ¹
• Mohammad Ahmadyousefi ²

¹ Department of Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

² Hamadan University of Medical Sciences, Hamadan, Iran

Abstract

Proven RNA-based medications have elevated the demand for targeted nucleic acid-based agents. In this study, nucleic acid aptamers represented an appropriate class of molecules. They are single-stranded nucleic acid molecules that bind to a target molecule with high affinity and specificity. Aptamers have a number of advantages over antibodies including compact dimenssions, rapid tissue penetration, heat resistance, denaturation resistance, broad spectrum of targets, ease of chemical synthesis, ease of chemical alteration, convenient storage, minimal immunogenic response, negligible variability across batches, and cost-effective production. Here, we evaluated whether we could use aptamers to target intracellular antigens and how they could be applied for delivering therapeutics or diagnostic agents to tumor or viral-infected cells.

Keywords

• Intracellular antigens
• nucleic acid aptamers
• TCR-like antibodies

Main Subjects

• Pharmaceutical sciences