Document Type : Review Article

Authors

• Sanaz Kavoosi ¹
• Sanam Rezazadeh Chafjiri ²
• Nastaran Asghari Moghaddam ³

¹ Department of biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran

² Department of Biotechnology, BA, Faculty of Basic Science, Ale-Taha Institute of Higher Education, Tehran, Iran

³ Department of Biology, Ph.D., Central Tehran Branch, Islamic Azad University, Tehran, Iran

Abstract

The gene Enhancer of Zeste Homolog 2 (EZH2) is shown to be involved in the progression of the angiogenesis in cancer including prostate cancer, also it is a well-known enzyme catalytic subunit, initially acting as a histone methyltransferase, to prevent expressing gene by trimethylating lysine at the histone H3 position. According to previous studies, it is obvious that in some cancer, such as prostate cancer, EZH2 is overexpressed. In this review, the regulation and function of the EZH2 gene and also signaling pathways that are regulated by this gene in angiogenesis process were reviewed. In addition, EZH2 has been playing an important role as a target in clinical trials to provide small inhibitor molecule that classified into two groups including new chemotherapy agents and repositioning drugs with the aim of cancer therapy and malignancy.

Keywords

• Prostate cancer
• EZH2
• signaling pathway
• angiogenesis
• repositioning drugs

Main Subjects

• Biological sciences