Polycystic Ovary Syndrome (PCOS) is the most common heterogeneous Endocrine (EC) disorder in women of childbearing age, which has an increasing trend in the number of patients recently. Although women with PCOS have been shown to triple the risk of EC compared to women without polycystic ovary syndrome, there are precise molecular mechanisms that increase the risk of EC in women with ovarian syndrome. Therefore, clinical strategies to prevent EC in PCOS are not well known. Although, elevated estrogen levels and decreased apoptosis have been suggested as potential mechanisms, there is no clarity on how these and other factors interact to increase the risk of EC in polycystic ovary syndrome. In this article, we try to review the functional mechanisms of TUBB8, SOX9 and BCL2 genes to examine their effect on controlling or promoting the risk of EC.