Volume 7 (2023-2024)
Volume 6 (2022-2023)
Volume 5 (2021-2022)
Volume 4 (2020-2021)
Volume 3 (2019-2020)
Volume 2 (2018-2019)
Volume 1 (2017-2018)
Number of Articles: 181
An overview of miRNAs role in neurofibromatosis type 2
Volume 7, Issue 2 , September 2023, , Pages 1-17
Abstract
Neurofibromatosis type 2 (NF2) is an autosomal dominant genetic condition that causes tumorigenicity of bilateral vestibular schwannomas. microRNAs (miRNA) are 22-25 nucleotides single-stranded class of non-coding RNAs that play an essential role in mRNA regulation, mostly negatively, in many human diseases, ... Read MoreA new frontier: Unveiling the possibility of targeting intracellular antigens with nucleic acid aptamers
Volume 7, Issue 3 , December 2023, , Pages 1-9
Abstract
Proven RNA-based medications have elevated the demand for targeted nucleic acid-based agents. In this study, nucleic acid aptamers represented an appropriate class of molecules. They are single-stranded nucleic acid molecules that bind to a target molecule with high affinity and specificity. Aptamers ... Read MoreComparison of methyl isoeugenol and methyl eugenol as renewable starting reagents for the synthesis of thiourea compounds for anti-Plasmodium falciparum
Volume 7, Issue 4 , March 2024, , Pages 1-23
Abstract
Several thiourea derivative compounds have been used as inhibitors of Plasmodium falciparum via the plasmepsin inhibition pathway. The thiourea derivative (compound 3) namely 1-{1-(3,4-dimethoxyphenyl)-4.6-bis[(3,4-dimethoxyphenyl)methyl]heptane-2-yl]-3-{[ (2E)-3-phenylprop-2-en-1-ylium-1-yl]amino}thiourea ... Read MoreIntroduction of CRISPR/Cas system, as a genetic interference pathway and essential factor in genome evolution
Volume 1, Issue 1 , June 2017, , Pages 3-23
Abstract
The clustered regularly interspaced short palindromic repeats / (CRISPR) associated protein system is an adaptive immune system in bacteria and archaea. This system mimics eukaryotic RNA interference (RNAi) system and can play an important role in gene regulation and immune system. CRISPR interference ... Read MoreHeme extract from horseradish peroxidase to use as nanomedicine for porphyria
Volume 2, Issue 1 , July 2018, , Pages 4-11
Abstract
Porphyria is a group of autosomal metabolic disorders which is characterized by genetic defects in heme biosynthesis pathway enzymes. The symptoms of the porphyria occur almost due to excess amount of heme precursors. Heme is a prosthetic group of hemoproteins including hemoglobin and essential enzymes ... Read MoreThe role of G9a gene in various cancers
Volume 1, Issue 3 , December 2017, , Pages 5-11
Abstract
G9a is an epigenetic regulator that methylate the lysine 9 of histone 3 and has a role in gene silencing. G9a generally causes repression of gene expression and participates in diverse cellular functions such as DNA repairing, proliferation and differentiation. This gene is overexpressed in some types ... Read MoreChemical aspects of antigen nano carriers for vaccine delivery
Volume 1, Issue 2 , September 2017, , Pages 5-24
Abstract
Scientists could take many approaches to design and classify vaccines against a microbe. These choices could be typically based on fundamental information about antigen carriers of vaccines, how to produce them synthetically and which chemical reactions involved for attaching antigen to carriers. This ... Read MoreTraditional herbal medicine in the treatment of patients infected with new Coronavirus
Volume 4, Issue 4 , March 2021, , Pages 6-15
Abstract
The purposes of this review was in the direction of epidemiology, causative agents, symptoms, vaccine research probabilities and COVID-19 infection novel Corona viruses that was investigated in China. The COVID-19 has surrounded viruses along with a practical sensation one stranded RNA genome and a nucleocapsid ... Read MoreInvestigation of chemical components and antibacterial activity of yarrow (Achillea wilhelmsii) extract
Volume 4, Issue 3 , December 2020, , Pages 6-18
Abstract
Herbal medicine is one of the oldest human approaches to treating diseases and yarrow (Achillea wilhelmsii) one of the most famous medicinal plants. Yarrow essential oil has anti-inflammatory, anti-spasm, anti-scalp, hair growth stimulation and topical skin healing due to chamazulene, cineole and borneol. ... Read MoreInvestigating cellular and molecular factors effective in leukemia and analyzing the immune system
Volume 6, Issue 2 , September 2022, , Pages 6-42
Abstract
Leukemia as one of the common cancers is still studied and needs improvement in diagnosis and treatment. In this study, we examined the activity of hematopoietic stem cells, which can be a precursor to leukemia. Hematopoietic cancer cells, by affecting the bone marrow, preserve the source of stem cells ... Read MoreSpecific signaling pathways and drugs play key role in regulation of angiogenesis
Volume 4, Issue 1 , June 2020, , Pages 7-37
Abstract
In this study, angiogenesis inducers and inhibitors and some important drugs are introduced. Abnormal angiogenesis can occur if the balance between inhibitory and inducible factors disappears. Angiogenesis inducers include EGF, FGF2, TGF-β, VEGF, G-CSF, HGF, TGF-α, IL-8, TNF-α and angiogenesis ... Read MoreThe frequency of hepatitis C virus genotypes with chronic hepatitis C referred to Nikopour clinic in Yazd
Volume 5, Issue 2 , September 2021, , Pages 7-13
Abstract
The aim of this study was to investigate the frequency of hepatitis C virus genotypes with chronic hepatitis C referred to Nikopour clinic of Yazd during 2010-2020. In this cross-sectional study RT-PCR was used to determine the genotype of hepatitis C virus. The patient information was recorded in a ... Read MoreOptimization of Vibrio fischeri bioluminescence property
Volume 3, Issue 1 , June 2019, , Pages 9-18
Abstract
Vibrio fischeri is a bacterium that produces light, mainly in sea water. The glowing light from luminous bacteria is a specific function consisting of luciferase and luciferin. This ability of V. fischeri is a valuable application for researchers. In this study, the growth conditions were optimized for ... Read MoreEZH2 expression role in angiogenesis of prostate malignancy
Volume 7, Issue 3 , December 2023, , Pages 10-29
Abstract
The gene Enhancer of Zeste Homolog 2 (EZH2) is shown to be involved in the progression of the angiogenesis in cancer including prostate cancer, also it is a well-known enzyme catalytic subunit, initially acting as a histone methyltransferase, to prevent expressing gene by trimethylating lysine at the ... Read MoreTherapy, incidence and trend of head and neck malignancies in Yazd, Iran
Volume 2, Issue 4 , March 2019, , Pages 11-21
Abstract
In this study, we investigated the incidence and trend of head and neck malignant tumors between 2004 and 2015 in Yazd, Iran. A database study was conducted using the tumor registry data which was taken from Shahid Sadoughi hospital in Yazd. This study consisted of 824 patients that 57.9 % were men and ... Read MoreAdvantages of selected natural and synthetic materials as scaffolds in vascular tissue engineering
Volume 6, Issue 3 , December 2022, , Pages 11-22
Abstract
The development of tissue engineering provides various opportunities to vascular tissue engineering. Scaffold plays an essential role in vascular tissue engineering. The selection of biomaterials used as scaffolds will determine the success of vascular tissue engineering. The structure of vascular system, ... Read MoreA novel approach for analysis of shared genetic architecture of drug response based on summary statistics from genome-wide association studies
Volume 3, Issue 3 , December 2019, , Pages 12-49
Abstract
The main objective of this study is to gain an exploratory sense of the relationships between the phenotypes (response to drugs) employing the genome‐wide association studies (GWAS) summary statistics for searching underlying contribution of pleiotropy across the associated SNPs to this relationship. ... Read MoreEvaluation of silver nanoparticles and alcoholic extract of Amaranthus retroflexus on pathogenic bacteria
Volume 2, Issue 3 , December 2018, , Pages 12-23
Abstract
In recent years, application of medicinal plants increase in the treatment of infections rather than antimicrobial drugs. The aim of this study was to compare the effects of silver nanoparticles and alcoholic extract of Amaranthus retroflexus on some pathogenic bacteria. The alcoholic extract of this ... Read MoreAn in silico study to find angiogenesis inhibitory role for Naja oxiana snake venom cytotoxins
Volume 2, Issue 1 , July 2018, , Pages 12-20
Abstract
Cytotoxins especially CTX-I and CTX-II are components in the venom of cobra snakes. Cytotoxins as apoptotic agents are appropriate candidates to study of anticancer drugs. In this study we performed docking analysis of CTX-I and CTX-II against vascular endothelial growth factor (VEGF) and its main receptor ... Read MoreSolid-liquid biphasic distributive bio systems; a novel method for removal of contaminants
Volume 1, Issue 3 , December 2017, , Pages 12-24
Abstract
Solid-liquid biphasic biosystems contains two phases; aqueous phase containing the microorganisms and polymeric solid phase. Non aqueous phase has various applications including faster removal of hydrophobic contaminants and release them to the aqueous environment for better decomposition by microorganisms, ... Read MoreBiotransformation of atropine, 4-hydroxy coumarin, 8-hydroxy quinoline, indole and penicillin G by the natural microflora
Volume 6, Issue 1 , June 2022, , Pages 13-25
Abstract
It has been found that natural microorganism have a siginificant role in the production and development of new medicines. The present study aimed to evaluat biotransformation of atropine, 4-hydroxy coumarin, 8-hydroxy quinoline, indole and industrially compound (penicillin G), arrive in the human body, ... Read MorePlant antioxidants and their evaluation
Volume 2, Issue 2 , October 2018, , Pages 14-18
Abstract
Antioxidants are substances at low concentrations and with a special mechanism which slow down or stop oxidation processes. Antioxidants are divided into two synthetic and natural categories. In this study, plants are the most important sources of antioxidants that could protect cells from oxidative ... Read MoreThe IFIH1 gene polymorphism (Ala946Thr) association with the type 2 diabetes mellitus and hypertension among Iraqi patients
Volume 5, Issue 2 , September 2021, , Pages 14-25
Abstract
Numerous genes with Single Nucleotide Polymorphisms (SNPs) are implicated in the Type 2 Diabetes Mellitus (T2DM) development. This work conducted as a case-control to assess the association of IFIH1 gene polymorphism (Ala946Thr) to the T2DM and hypertension among Iraqi patients. A total of 100 T2DM patients ... Read MoreEvaluation of the pattern of COVID-19 infection in hospital staff in Iran
Volume 6, Issue 4 , March 2023, , Pages 14-24
Abstract
Health-care workers are one of the most at-risk groups in Covid-19 pandemic. The aim of this study was to investigate the pattern of Covid-19 among hospital employees. Among the participants there were 58 % nurses, 12 % physicians, 26 % other wards paraclinical and 4 % service personnel. ... Read MoreThe Frequency of causes of vaginitis with Pap smear test in patients specially based on age as an effective agent on genetic factors
Volume 5, Issue 1 , June 2021, , Pages 15-23