Document Type : Original Research Article

Abstract

Cytotoxins especially CTX-I and CTX-II are components in the venom of cobra snakes. Cytotoxins as apoptotic agents are appropriate candidates to study of anticancer drugs. In this study we performed docking analysis of CTX-I and CTX-II against vascular endothelial growth factor (VEGF) and its main receptor (VEGFR2) that are the main key factors of angiogenesis. The results showed that CTX-I has higher binding affinity to VEGF and VEGFR2 compare to its native ligand, so it could be a suitable candidate to study anticancer drug.

Keywords

• Cytotoxin
• venom
• Naja oxiana snake