In this study, we investigated the incidence and trend of head and neck malignant tumors between 2004 and 2015 in Yazd, Iran. A database study was conducted using the tumor registry data which was taken from Shahid Sadoughi hospital in Yazd. This study consisted of 824 patients that 57.9 % were men and 42.1 % were women. The mean age of patients was 54.31 ±17.18 years. Thyroid, larynx and skin cancers were the most common cancers. The most frequent malignancy was Laryngeal carcinoma in men and thyroid carcinoma in women. The age distribution of patients showed a higher peak in men than women and also the median age in women was lower in men. Overall the trend in male and female patient number was ascending. According to the increasing trend of head and neck cancers in Yazd, it is recommended that to identify risk factors and vulnerable groups in order to reduce the burden of these types of cancers. It is necessary to inform the trend of incidence for health planning.