Document Type : Review Article



In this study, angiogenesis inducers and inhibitors and some important drugs are introduced. Abnormal angiogenesis can occur if the balance between inhibitory and inducible factors disappears. Angiogenesis inducers include EGF, FGF2, TGF-β, VEGF, G-CSF, HGF, TGF-α, IL-8, TNF-α and angiogenesis inhibitors such as endostatin, interleukin, prolactin, interferons, IL-1, IL-12, angiostatin, and IL-18. On the other hand, many drugs can affect these signaling pathways.