Numerous genes with Single Nucleotide Polymorphisms (SNPs) are implicated in the Type 2 Diabetes Mellitus (T2DM) development. This work conducted as a case-control to assess the association of IFIH1 gene polymorphism (Ala946Thr) to the T2DM and hypertension among Iraqi patients. A total of 100 T2DM patients were enrolled, 50 of them had hypertension. Moreover, 100 subjects were healthy that used as control group. All participants were genotyped using Real Time Polymerase Chain Reaction (RT-PCR). The G allele was more frequent in T2DM+ Hypertension (HTN) and T2DM without HTN (0.51 % and 0.52 %, respectively), while were less frequent (0.425 %) in the control group. The AA genotype was a significant risk factor for T2DM -HTN development. The GA genotype was also significantly (p <0.01 and OR: 5.8-8.3 associated, while the combination of the genotypes GA and AA depicted a significant P value<0.03 and OR of 4.42. The GA genotype was significantly related to the T2DM without hypertension.