Comparison of the transmission and detection potential of COVID-19 virus and other viruses in tear fluids
Volume 4, Issue 4 , March 2021, , Pages 16-31

https://doi.org/10.22034/HBB.2021.03

Abstract
  The COVID-19 virus is a subgroup of zoonotic viruses. The most terrible problem started when the number of infected patients with acute respiratory syndrome quickly spread around the world, which made it as a global pandemic. This novel virus could transmitted from person to person via infected droplet ...  Read More

In silico docking of matrix metalloproteinase inhibitors of Hemiscorpius Lepturus to human matrix metalloproteinases - opportunities for novel natural therapeutics
Volume 3, Issue 2 , September 2019, , Pages 16-39

https://doi.org/10.22034/HBB.2019.15

Abstract
  Hemiscorpius Lepturus is one of the most dangerous scorpion species in Iran. Four metalloproteinase inhibitors were detected in the transcriptome of venom gland of H.lepturus (HLMetInhibit1, HLMetInhibit2, HLMetInhibit3 and HLMetInhibit4). Their secondary and 3D structures were predicted using Iterative ...  Read More

Evaluating the level of knowledge of people referring to the comprehensive health services center about crimean congo hemorrhagic fever
Volume 5, Issue 3 , December 2021, , Pages 17-22

https://doi.org/10.22034/HBB.2021.20

Abstract
  Since crimean congo hemorrhagic fever can be prevented with simple methods, people awareness and prevention of this disease is important. In this study, the level of knowledge about this disease and the factors affecting the knowledge of people were investigated in Yazd. In this study, 220 people referred ...  Read More

Biological sciences
A review of similarity of KLF2, MSX1 and SOX9 genes expression in zebrafish and human

Mehdi Ahmadifar; Reihaneh Balali; sadaf reihani; zeinab jarban

Volume 7, Issue 2 , September 2023, , Pages 18-34

https://doi.org/10.22034/HBB.2023.15

Abstract
  In recent studies, the focus on zebrafish, as a suitable laboratory model for studying vertebrate gene function, has increased dramatically. We evaluated the similarity between the three genes KLF2, MSX1 and SOX9 in humans and zebrafish. The KLF2 gene plays a role in heart and immunity of humans and ...  Read More

Quantitative evaluation of DYT1 promoter methylation in dystonia patients
Volume 4, Issue 3 , December 2020, , Pages 19-27

https://doi.org/10.22034/HBB.2020.15

Abstract
  This study aimed at assessing the methylation state of the DYT1 gene in the pathogenesis of dystonia disease and evaluated the clinical feature. Thirty patients with no mutation in DYT1 gene and 30 normal individuals were investigated. The methylation of promoter in DYT1 gene was investigated using Real-time ...  Read More

Replication of pgR107 binary Ti vector without pSoup helper plasmid in disarmed Agrobacterium tumefaciens LBA4404
Volume 3, Issue 1 , June 2019, , Pages 19-28

https://doi.org/10.22034/HBB.2019.09

Abstract
  Nowadays the dual binary vector system pGreen/pSoup is used for Agrobacterium transformation. The pGreen vector uses the pSa replication locus composed of the pSa ori and the pSa replicase gene (repA). The repA gene is resident on a pSoup and provides replication functions in Trans for pGreen. Therefore, ...  Read More

The survey of nosocomial infections in Yazd clinical settings during 2016
Volume 2, Issue 2 , October 2018, , Pages 19-26

https://doi.org/10.22034/HBB.2018.17

Abstract
  In this study, we aimed to survey the health care in public hospitals in 2016 in three public hospitals in Yazd, since the level of hospital hygiene plays an important role in the incidence of nosocomial infections in patients admitted to hospital. The method of data collection was a form of the hygiene ...  Read More

Evaluation of industrial cosmetic products and replacing them with natural products according to modern, traditional and islamic medicine
Volume 1, Issue 4 , March 2018, , Pages 19-31

https://doi.org/10.22034/HBB.2018.02

Abstract
  Nowadays, cosmetic products are used excessively and there are cosmetic products in daily shopping basket of women. One of the public health issue is the possibility of transmission of pathogens by cosmetic products which are not standard and lead to an increase in the risk of various skin diseases and ...  Read More

Design and synthesis of short antimicrobial peptide derivatives based on human cathelicidin
Volume 3, Issue 4 , March 2020, , Pages 21-34

https://doi.org/10.22034/HBB.2020.27

Abstract
  Cathelicidin derived from human leukocytes is a 171amino acid protein that demonstrated to have antimicrobial activity. Synthesis of Antimicrobial Peptides (AMPs) are known to be expensive. In this study, after extraction of human cathelicidin sequence from NCBI, physicochemical characteristics such ...  Read More

Examining of the quality and quantity of active ingredients of Smirnova iranica Sabeti in different habitats
Volume 2, Issue 1 , July 2018, , Pages 21-27

https://doi.org/10.22034/HBB.2018.11

Abstract
  In this study, four sites were chosen in the habitat of the plant which are located in Kashan. In order to complete phytochemical studies during flowering in each site, leaves were collected and after extraction of essential oils by simultaneous method of distillation and extraction using organic solvents, ...  Read More

Study on DNA conformational transition affected by extremely low frequency magnetic field
Volume 2, Issue 4 , March 2019, , Pages 22-31

https://doi.org/10.22034/HBB.2019.03

Abstract
  Increased application of electrical devices and consequent expansion of electrical distribution network, expose us to extremely low frequency electromagnetic fields (ELF-EMF) more than ever. Mechanisms of action of ELF-EMFs on cells and biomolecules are not well understood. Presence of specific sequence ...  Read More

Biological sciences
The golden doses of anti CD3/CD28 microbeads plus IL-15 promote expansion of specific T cells in human cytomegalovirus adaptive immunotherapy

Arsalan Jalili; Nasser Aghdami; Abbas Hajifathali; Maryam Sayahinouri

Volume 7, Issue 1 , July 2023, , Pages 22-45

https://doi.org/10.22034/HBB.2023.09

Abstract
  In this study, the use of anti-CD3/CD28 magnetic microbeads and IL-15 in the culture of T lymphocytes in vitro had a significant role in the proliferation and cytotoxicity of these cells. Peripheral blood mononuclear cells of 6 (Cytomegalovirus) HCMV positive volunteers were harvested, then the pure ...  Read More

Cardioprotective effects of extract of Sclerocarya birrea stem bark on doxorubicin induced cardiotoxicity in rats
Volume 5, Issue 3 , December 2021, , Pages 23-43

https://doi.org/10.22034/HBB.2021.21

Abstract
  This study aimed to investigate the protective effect of methanol extract of Sclerocarya birrea (S. birrea) stem bark on Doxorubicin (DOX) induced cardiotoxicity in rats. Tissue Malondialdehyde (MDA) level was increased in DOX treated group while activities of antioxidant maker enzymes; Catalase (CAT), ...  Read More

Effect of Ajwa Date (Phoenix dactilyfera L.) extract in aspirin induced peptic ulcer model

Hendri Busman; Winda Trijayanthi Utama; Rizki Hanriko; Jason Mikail Amper; Indriyani Indriyani

Volume 6, Issue 3 , December 2022, , Pages 23-32

https://doi.org/10.22034/HBB.2022.21

Abstract
  Dates have been used to ameliorate various gastrointestinal diseases. This study aimed to evaluate the gastroprotective effect of ajwa dates extract on rats induced by aspirin. Rats were divided into five groups using a completely randomized design. Group 1 received only 300 mg/kg BW aspirin. Group 2 ...  Read More

Investigation of slow freezing of human testicular tissue on proliferation, colonization and viability of human spermatogonial stem cells
Volume 2, Issue 3 , December 2018, , Pages 24-35

https://doi.org/10.22034/HBB.2018.24

Abstract
  In this study, the effects of freezing of testicular tissue by slow freezing on the proliferation rate, colonization and viability of spermatogonial stem cells (SSCs) were evaluated. The testicular tissue of the freezing group was freezed by slow-freezing method, and the fresh group remained intact. ...  Read More

Anthocyanins and digestive system cancers
Volume 1, Issue 1 , June 2017, , Pages 24-34

https://doi.org/10.22034/HBB.2017.02

Abstract
  The international community suffers from spread digestive system cancers. Hence, our goal was evaluation of anthocyanins efficiency in digestive system cancers improvement. As the result, researchers have declared that anthocyanins have a protective role in digestive system cancers. Also, due to health ...  Read More

In-vitro dose response effect of bergenin on platelet aggregation by inhibiting inducers (collagen and ADP) and lipoxygenase
Volume 5, Issue 1 , June 2021, , Pages 24-38

https://doi.org/10.22034/HBB.2021.09

Abstract
  In this study, we investigated the anti-platelet activity of bergenin on platelet aggregation induced by collagen and ADP on blood sample of healthy volunteers (18–40 years). Blood sample was centrifuge and Platelet Rich Plasma (PRP) was carefully collected in tube. Lipoxygenase inhibition activity ...  Read More

Biological sciences
GC/MS analysis and antifungal activity of M. Chamomilla extracts against molecularly identified keratinophilic fungi

Afrah Talib Abdullah; kadhim F Kadhim

Volume 7, Issue 4 , March 2024, , Pages 24-43

https://doi.org/10.22034/HBB.2024.02

Abstract
  The objective of this study was to isolate and genetically identify keratinophilic fungi associated with humans, test their susceptibility to nystatin, and evaluate the effectiveness of Methanol Extract (ME) from chamomile flowers against these fungi. No cytotoxic effects were observed in the extract ...  Read More

Evaluating antimicrobial effects of different orange blossom extract (Citrus aurantium L) on microbial species in vitro
Volume 1, Issue 3 , December 2017, , Pages 25-36

https://doi.org/10.22034/HBB.2017.16

Abstract
  Citrus aurantium L is rich of flavonoids, many flavones, volatile compounds and monoterpenes hydrocarbons. Orange blossom extract has antioxidant and antimicrobial features. In Iranian traditional medicine, orange blossom is known as a comforting and sleep booster plant. According to disrupt and side ...  Read More

Optimization of cyclotide like peptide extraction methods and characterization of these peptides from Viola tricolor
Volume 1, Issue 2 , September 2017, , Pages 25-38

https://doi.org/10.22034/HBB.2017.09

Abstract
  Cyclotides are antimicrobial peptides and play significant role as bio preservative in the food industry. Since foodborne diseases are a universal issue, in the present study the different methods for partial purification of cyclotide like peptides from Viola tricolor were compared and the antimicrobial ...  Read More

Pharmaceutical sciences
Experimental studies and artificial neural networks (ANN) modeling of asparaginase partitioning in aqueous two-phase systems: Polyethylene glycol and inorganic salts

Mohsen Mesbahi-Nowrouzi; Soroush Sardari

Volume 6, Issue 4 , March 2023, , Pages 25-42

https://doi.org/10.22034/HBB.2023.03

Abstract
  This article studied applicabilities of Artificial Neural Networks (ANN), aiming at partitioning of Asparaginase (ASP). The first step investigated the partitioning of ASP using ATPS, consisting of polyethylene glycol and different inorganic salts. The studies of ASP partition were conducted ...  Read More

The rate of smoking and drug addiction among patients with COVID-19 specially based on sex genetic factor
Volume 5, Issue 2 , September 2021, , Pages 26-33

https://doi.org/10.22034/HBB.2021.16

Abstract
  The aim of this study was to determine the extent of tobacco and drug addiction to opium, methamphetamine and heroin in hospitalized patients due to COVID-19. In this cross-sectional descriptive study, the rate of smoking and drug addiction among COVID-19 patients admitted to Shahid Sadoughi hospital ...  Read More

Pharmaceutical sciences
Oral and oropharyngeal cancers: global status, needs and recent developments in treatment

Neeraja Podichety; Sivakumar Ramaiah

Volume 5, Issue 4 , March 2022, , Pages 26-44

https://doi.org/10.22034/HBB.2022.02

Abstract
  Oral and oropharyngeal cancers are a large group of cancers that fall under the category of cancer of the head and neck. Current therapy includes surgery and radiotherapy associated with extreme morbidity and a decline in the quality of life. At advanced stages, oral cancer is often diagnosed and has ...  Read More

Medicinal sciences
Relationship between blood albumin level and clinical condition of patients with Covid-19 admitted to Shahid Sadoughi hospital in Yazd

Mahdie Hamidfar; Seyed Hossein shahcheraghi; Faezehsadat Heidari; Kazem Ansari; Tahere Fallah

Volume 6, Issue 1 , June 2022, , Pages 26-32

https://doi.org/10.22034/HBB.2022.09

Abstract
  COVID-19 infection is still widespread around the world. It has been demonstrated that albumin is a biomarker in COVID-19 diagnosis. The aim of this study was to investigate the relationship between blood albumin and clinical status of COVID-19 patients. In our study, patients older than 18 years admitted ...  Read More

A comparative study on microencapsulation of tryptophan synthase using Escherichia coli whole cells entrapped in different natural polymers
Volume 2, Issue 2 , October 2018, , Pages 27-37

https://doi.org/10.22034/HBB.2018.18

Abstract
  Tryptophan (L-Trp) is a fundamental precursor to a number of drugs. In this research, three natural polymers included agar, agarose and alginate were investigated for immobilization of E. coli cells for L-Trp production to increase enzymatic stability. Also, the capability of beet molasses as serin (L-Ser) ...  Read More