Since crimean congo hemorrhagic fever can be prevented with simple methods, people awareness and prevention of this disease is important. In this study, the level of knowledge about this disease and the factors affecting the knowledge of people were investigated in Yazd. In this study, 220 people referred to the comprehensive health services center in Yazd were included in the study and a questionnaire of knowledge of people level was completed. Then the obtained information was entered into statistical software. Only 30 % of people were aware of crimean congo hemorrhagic fever.