Novel target of the 4-piperidone thiazole derivative for platelet inhibitions by using inducers collagen and ADP
Volume 5, Issue 3 , December 2021, Pages 1-16

https://doi.org/10.22034/HBB.2021.19

Abstract
  Platelets are thought to aid in hemostasis, thrombosis, inflammation, wound healing, and immunity. R4 is a novel thiazole derivative that may decrease angina and ischemia. An aggregometer evaluated R4 impact on PRP. Spectrophotometric method measured anti-lipoxygenase activity of R4. In its absence, ...  Read More

Evaluating the level of knowledge of people referring to the comprehensive health services center about crimean congo hemorrhagic fever
Volume 5, Issue 3 , December 2021, Pages 17-22

https://doi.org/10.22034/HBB.2021.20

Abstract
  Since crimean congo hemorrhagic fever can be prevented with simple methods, people awareness and prevention of this disease is important. In this study, the level of knowledge about this disease and the factors affecting the knowledge of people were investigated in Yazd. In this study, 220 people referred ...  Read More

Cardioprotective effects of extract of Sclerocarya birrea stem bark on doxorubicin induced cardiotoxicity in rats
Volume 5, Issue 3 , December 2021, Pages 23-43

https://doi.org/10.22034/HBB.2021.21

Abstract
  This study aimed to investigate the protective effect of methanol extract of Sclerocarya birrea (S. birrea) stem bark on Doxorubicin (DOX) induced cardiotoxicity in rats. Tissue Malondialdehyde (MDA) level was increased in DOX treated group while activities of antioxidant maker enzymes; Catalase (CAT), ...  Read More

Construction of a chimeric FliC including epitopes of OmpA and OmpK36 as a multi-epitope vaccine against Klebsiella pneumonia
Volume 5, Issue 3 , December 2021, Pages 44-60

https://doi.org/10.22034/HBB.2021.22

Abstract
  OmpA and OmpK36 from K. pneumoniae as the antigens and FliC from Salmonella typhimurium as the adjuvant were applied to construct a multi-epitope vaccine. B-cell, T-cell, and IL-17-epitopes were identified and a construct was modeled. Molecular docking was performed to assess the interaction between ...  Read More

The most common symptoms of COVID-19 patients in Yazd
Volume 5, Issue 3 , December 2021, Pages 61-71

https://doi.org/10.22034/HBB.2021.23

Abstract
  The aim of this study was to investigate the most common symptoms of COVID-19 patients in Yazd. This study was done during 2020-2021. All patients with positive PCR test were entered to this study. Finally, data was analyzed by SPSS software. The most common symptoms of COVID-19 patients were shortness ...  Read More

Strategies in design of antibodies for cancer treatment
Volume 5, Issue 3 , December 2021, Pages 72-96

https://doi.org/10.22034/HBB.2021.24

Abstract
  Structural bioinformatics and computational methodologies facilitate antibodies design. The rational design is used to achieve a new function or adopt a new structure. Computer algorithms can systematically search amino acid sequences and select the best one. One of the important points of protein therapeutics ...  Read More