Document Type : Original Research Article



This study aimed at assessing the methylation state of the DYT1 gene in the pathogenesis of dystonia disease and evaluated the clinical feature. Thirty patients with no mutation in DYT1 gene and 30 normal individuals were investigated. The methylation of promoter in DYT1 gene was investigated using Real-time PCR technique. There was no significant difference in methylation status of DYT1 gene promoter in the dystonia patients compared with normal individuals, showed that the methylation of promoter in DYT1 gene had no important role in dystonia. Also, the methylation of promoter in DYT1 gene was observed with higher frequency in the generalized type, suggesting that the methylation of this gene may play a role in pathogenesis of this type of dystonia.


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