Document Type : Original Research Article

Authors

• Hendri Busman ¹
• Winda Trijayanthi Utama ²
• Rizki Hanriko ³
• Jason Mikail Amper ³
• Indriyani Indriyani ⁴

¹ Soemantri Brojonegoro No. 1 Street, Gedung Meneng, Bandar Lampung

² Department of Public Health, Faculty of Medicine, Bandar Lampung, Lampung, Indonesia

³ Department of Pathology, Faculty of Medicine, Bandar Lampung, Lampung, Indonesia

⁴ Department of Biology, Faculty of Mathematics and Natural Sciences, Bandar Lampung, Lampung, Indonesia

Abstract

Dates have been used to ameliorate various gastrointestinal diseases. This study aimed to evaluate the gastroprotective effect of ajwa dates extract on rats induced by aspirin. Rats were divided into five groups using a completely randomized design. Group 1 received only 300 mg/kg BW aspirin. Group 2 received 25.2 mg/kg BW omeprazole and aspirin 300 mg/kg BW. Groups 3, 4, and 5 received 250, 500, and 1.000 mg/kg BW ajwa dates extract and 300mg/kg BW aspirin, respectively, during 6 h. At the end of the examination, the average gaster damage score was 1.36, 0.24, 0.96, 0.68, and 0.80, in groups 1, 2, 3, 4, and 5, respectively. The 500 and 1.000 mg/kg BW doses of ajwa dates extract significantly reduced the gaster damage score. It is suggested that the extract of the ajwa date could be utilized as a gastroprotective agent.

Keywords

• Aspirin
• Ajwa date extract
• gastroprotective