Hypothesis of a potential antiviral drug

Kevin Ricardo Espinosa

Volume 6, Issue 3 , December 2022, Pages 1-10


  The approval of mRNA vaccine technique against COVID-19 opens a door to research and the creation of new drugs against different infectious pathologies or even cancer, since for several diseases the therapeutic options are limited, and different viral diseases are treated only symptomatically. For these ...  Read More

Advantages of selected natural and synthetic materials as scaffolds in vascular tissue engineering

Helsy Junaidi; Jeanne Adiwinata Pawitan

Volume 6, Issue 3 , December 2022, Pages 11-22


  The development of tissue engineering provides various opportunities to vascular tissue engineering. Scaffold plays an essential role in vascular tissue engineering. The selection of biomaterials used as scaffolds will determine the success of vascular tissue engineering. The structure of vascular system, ...  Read More

Effect of Ajwa Date (Phoenix dactilyfera L.) extract in aspirin induced peptic ulcer model

Hendri Busman; Winda Trijayanthi Utama; Rizki Hanriko; Jason Mikail Amper; Indriyani Indriyani

Volume 6, Issue 3 , December 2022, Pages 23-32


  Dates have been used to ameliorate various gastrointestinal diseases. This study aimed to evaluate the gastroprotective effect of ajwa dates extract on rats induced by aspirin. Rats were divided into five groups using a completely randomized design. Group 1 received only 300 mg/kg BW aspirin. Group 2 ...  Read More

Formulation development of Ezetimibe by using Soluplus and Co- Processed Acacia: tragacanth with Design Expert

TarakaRamarao Ch; Ravali Jami

Volume 6, Issue 3 , December 2022, Pages 33-56


  Ezetimibe is an antihyperlipidemic drug that lowers cholesterol levels. The purpose of this study was to compare different amounts of solid dispersions and formulations using various carriers in order to improve the dissolution. The Design Expert software was used to perform Analysis of Variance (ANOVA), ...  Read More

Biological sciences
Whole exome sequencing reveals the first c.7456C>T p.Arg2486X mutation in ATM gene in Iranian population

Saeed Dorgaleleh; Karim Naghipoor; Teymoor Khosravi; Amin Tadayoni Nia; Elham Sheikhi Ghayur; Hamayon abdul Aziz; Morteza Oladnabi

Volume 6, Issue 3 , December 2022, Pages 57-72


  Mutations in Ataxia-Telangiectasia Mutated (ATM) gene are prominently responsible for the condition. ATM gene encodes a serine/threonine protein kinase, a crucial component in DNA repair systems. Whole exome sequencing was performed on a nine year old male subject with clinical features of A-T. Alpha ...  Read More

Medicinal sciences
Isolation of MDR Providencia stuartii from tracheal aspirates of two hospitalized patients

Niloofar Rezaie; Shadi Agghamohammad; Mahdi Rohani; Abdolreza Javadi; Farzad Badmasti; Armaghan Soltani Shirazi

Volume 6, Issue 3 , December 2022, Pages 73-79


  The emergence of nosocomial infection due to Multi-Drug Resistant (MDR) bacteria is a challenge to infection control. This study presented two Providencia species from two hospitalized patients admitted to Imam Hussein hospital in Iran. Biochemical and molecular tests were performed for the identification ...  Read More