Biological sciences
Polyherbal formulation: An alternative therapeutic approach to treat diabetic foot ulcer

Debasmita Dubey; Shakti Rath; Rajesh Kumar Meher; Siba Prasad Dalai; Jayant Kumar Dash; Santosh Kumar Swain

Volume 6, Issue 4 , March 2023, Pages 1-13

  Diabetic Foot Ulcers (DFUs) are a common complication of poorly controlled diabetes and often become infected, termed diabetic foot infection. Despite using several multidisciplinary techniques, no significant cure is still achievable. So, it needs an alternative therapeutic approach to treat diabetic ...  Read More

Medicinal sciences
Evaluation of the pattern of COVID-19 infection in hospital staff in Iran

Ali Dehghani Ahmadabad; Zohreh AkhoundiMeybodi; Ehsan Rezaeinejad

Volume 6, Issue 4 , March 2023, Pages 14-24

  Health-care workers are one of the most at-risk groups in Covid-19 pandemic. The aim of this study was to investigate the pattern of Covid-19 among hospital employees. Among the participants there were 58 % nurses, 12 % physicians, 26 % other wards paraclinical and 4 % service personnel. ...  Read More

Pharmaceutical sciences
Experimental studies and artificial neural networks (ANN) modeling of asparaginase partitioning in aqueous two-phase systems: Polyethylene glycol and inorganic salts

Mohsen Mesbahi-Nowrouzi; Soroush Sardari

Volume 6, Issue 4 , March 2023, Pages 25-42

  This article studied applicabilities of Artificial Neural Networks (ANN), aiming at partitioning of Asparaginase (ASP). The first step investigated the partitioning of ASP using ATPS, consisting of polyethylene glycol and different inorganic salts. The studies of ASP partition were conducted ...  Read More

Medicinal sciences
Stem cells used in infectious diseases like pneumonia, respiratory infections and Covid-19: A study based on doctor’s opinion

Swati Chaudhary; Supriti Agrawal

Volume 6, Issue 4 , March 2023, Pages 43-55

  Worldwide, infectious diseases have contributed significantly to morbidity and mortality; among the leading causes of death are pneumonia, respiratory infections and Covid-19. Stem cell therapy will be used to treat virus-infected patients in an effective and safe manner. A crosssectional ...  Read More

Biological sciences
Induction and evaluation of influenza cell-mediated immune responses by HA2 subunit and bio adjuvant as a gene vaccine candidate

Sina Soleimani; Mohammadreza Ghorani

Volume 6, Issue 4 , March 2023, Pages 56-66

  The stalk domain of influenza as Hemagglutinin 2 (HA2) is a conserved unit of HA and is a candidate for a vaccine construct. We designed HA2/Mx (Myxovirus Resistance) as bio adjuvant construct for vaccine candidates. After immunization of Razi Balb/c mice in DNA/prime/boost strategy, for determination ...  Read More

Determination of CAPN11 and UBQLN3 gene expression in men with Non-Obstructive Azoospermia

Masoud Salehipour; Masoumeh Karimi

Volume 6, Issue 4 , March 2023, Pages 67-80

  Genetic disorders play an important role in male infertility, especially in Non-Obstructive Azoospermia (NOA). Many studies have been performed on the expression profiles of gonadal genes in order to accurately identify the genes involved in impaired spermatogenesis. In the current study, testicular ...  Read More

One pot, green synthesis and biological evaluation of some isatin-based thiocarbohydrazones derivatives

Seyyed Mohammad Shahcheragh; Azizollah Habibi; Masoomeh Shirzad; Yekta Farahani; Soroush Sardari

Volume 6, Issue 4 , March 2023, Pages 81-97

  In the present study, a one-pot, green and three-component route for synthesis of Thiocarbohydrazone (TCS) derivatives is described. This reaction was performed in choline chloride/urea (1:2) as Deep Eutectic Solvent (DES). The structures were characterized by FTIR, 1H NMR, 13C NMR spectra and elemental ...  Read More