Volume 7 (2023-2024)
Volume 6 (2022-2023)
Volume 5 (2021-2022)
Volume 4 (2020-2021)
Volume 3 (2019-2020)
Volume 2 (2018-2019)
Volume 1 (2017-2018)
Main Subjects = Pharmaceutical sciences
Number of Articles: 10
Comparison of methyl isoeugenol and methyl eugenol as renewable starting reagents for the synthesis of thiourea compounds for anti-Plasmodium falciparum
Volume 7, Issue 4 , March 2024, , Pages 1-23
Abstract
Several thiourea derivative compounds have been used as inhibitors of Plasmodium falciparum via the plasmepsin inhibition pathway. The thiourea derivative (compound 3) namely 1-{1-(3,4-dimethoxyphenyl)-4.6-bis[(3,4-dimethoxyphenyl)methyl]heptane-2-yl]-3-{[ (2E)-3-phenylprop-2-en-1-ylium-1-yl]amino}thiourea ... Read MoreIpragliflozin protect from acute pulmonary injury induced by endotoxemia in mouse model via NF-KB pathway
Volume 7, Issue 4 , March 2024, , Pages 98-113
Abstract
Sepsis is now more commonly regarded as an uncontrolled inflammatory and immune response throughout the body, triggered by microbial invasion and resulting in high mortality rate from organ damage. This study aimed to demonstrate the protective impact of ipragliflozin on lung damage induced in mice by ... Read MoreA new frontier: Unveiling the possibility of targeting intracellular antigens with nucleic acid aptamers
Volume 7, Issue 3 , December 2023, , Pages 1-9
Abstract
Proven RNA-based medications have elevated the demand for targeted nucleic acid-based agents. In this study, nucleic acid aptamers represented an appropriate class of molecules. They are single-stranded nucleic acid molecules that bind to a target molecule with high affinity and specificity. Aptamers ... Read MoreIntroducing an innovative algorithm based on the abilities of the human perception system towards profiling similarity search of drugs and drug-like compounds such as fluoxetine
Volume 7, Issue 3 , December 2023, , Pages 62-76
Abstract
The current research had been finalized based on the employing interdisciplinary aspects in addition to utilizing skills of cheminformatics in addition to psychosomatic facts towards introducing the innovative Translator Machine System (TMS-CH) for converting small molecule structures to melodic composition ... Read MoreThermal stability and pH of antioxidant activity of ethanol extract of Ciplukan herbs (Physalis angulata Linn) along with determination of pKa
Volume 7, Issue 2 , September 2023, , Pages 52-65
Abstract
In this study, thermal stability and pH for the antioxidant activity of the ethanol extract of ciplukan (Physalis angulata Linn) herbs had been studied. Among the antioxidant activity methods, the use of DPPH (2,2-diphenyl-1-picrylhydrazyl) reagent is simple and easy to use. The thermal effect was observed ... Read MoreIncreased risk of cerebral dysfunction by high-fructose diet consumption: A 90 -day study in female rats
Volume 7, Issue 2 , September 2023, , Pages 82-100
Abstract
Our study was designed to evaluate any changes in the liver, kidney, and brain tissues of female wistar rats to a fructose-enriched diet. Rats were divided into three groups (n=5/group). Monitoring of daily water-food consumption and clinical changes continued for 90 days. Afterward, the alteration of ... Read MoreInvestigating the protective effect of the methanolic extract of Salvia multicaulis on renal ischemia-reperfusion injuries in rats
Volume 7, Issue 1 , July 2023, , Pages 60-77
Abstract
In this research the protective effects of the methanolic extract of S. multicaulis was evaluated in renal ischaemia-reperfusion injuries in rats. 42 male rats were divided into 6 groups. In the treatment groups 1-3, before causing ischemia in the kidneys, rats received 50, 100, and 150 mg/kg/day doses ... Read MoreExperimental studies and artificial neural networks (ANN) modeling of asparaginase partitioning in aqueous two-phase systems: Polyethylene glycol and inorganic salts
Volume 6, Issue 4 , March 2023, , Pages 25-42
Abstract
This article studied applicabilities of Artificial Neural Networks (ANN), aiming at partitioning of Asparaginase (ASP). The first step investigated the partitioning of ASP using ATPS, consisting of polyethylene glycol and different inorganic salts. The studies of ASP partition were conducted ... Read MoreOral and oropharyngeal cancers: global status, needs and recent developments in treatment
Volume 5, Issue 4 , March 2022, , Pages 26-44
Abstract
Oral and oropharyngeal cancers are a large group of cancers that fall under the category of cancer of the head and neck. Current therapy includes surgery and radiotherapy associated with extreme morbidity and a decline in the quality of life. At advanced stages, oral cancer is often diagnosed and has ... Read MoreDNA damage protection by fatty acid rich fractions from Andrographis Paniculata Nees (AP): An in vitro study
Volume 5, Issue 4 , March 2022, , Pages 55-85