Early detection of melanoma with synchrotron radiation X-ray fiber diffraction analysis
Volume 1, Issue 2 , September 2017, Pages 1-4


  Skin is the largest organ in our body protecting us from ultraviolet radiation and xenobiotics. The function of keratinocytes is to form the impermeable barrier for the skin and rest of the body, whereas melanocytes provide the pigment for the keratinizing skin layers to protect the integrity of keratinocytes, ...  Read More

Chemical aspects of antigen nano carriers for vaccine delivery
Volume 1, Issue 2 , September 2017, Pages 5-24


  Scientists could take many approaches to design and classify vaccines against a microbe. These choices could be typically based on fundamental information about antigen carriers of vaccines, how to produce them synthetically and which chemical reactions involved for attaching antigen to carriers. This ...  Read More

Optimization of cyclotide like peptide extraction methods and characterization of these peptides from Viola tricolor
Volume 1, Issue 2 , September 2017, Pages 25-38


  Cyclotides are antimicrobial peptides and play significant role as bio preservative in the food industry. Since foodborne diseases are a universal issue, in the present study the different methods for partial purification of cyclotide like peptides from Viola tricolor were compared and the antimicrobial ...  Read More

Optimization of green synthesis of ZnO nanoparticles by Dittrichia graveolens (L.) aqueous extract
Volume 1, Issue 2 , September 2017, Pages 39-49


  In this work, we reported synthesis of ZnO nanoparticles (ZnONPs) by green procedure. A simple and effective synthesis of ZnONPs was performed by Dittrichia graveolens aqueous extract. The effect of three parameters including pH of the Zinc solution (4.0, 6.0 and 8.0), time (40, 60 and 120 min) and extract ...  Read More

Association scrutiny between the miRNA 148a/152 polymorphisms and risk of breast cancer in Isfahan population
Volume 1, Issue 2 , September 2017, Pages 50-60


  Breast cancer is 26% of diagnosed cancer in 2008 and it is second cause of cancer related deaths in women. This type of cancer is a complex genetic disease, because microRNAs (miRNAs) are expressional regulators of genes, genetic variations such as single nucleotide polymorphisms in their genes. Therefore, ...  Read More

Association study of leptin and leptin receptor gene polymorphisms with diabetes type 2 and obesity
Volume 1, Issue 2 , September 2017, Pages 61-69


  The adiposity hormone, leptin, plays an important role in the control of glucose metabolism by its action in the brain. The effects of leptin are reducing body adiposity, food intake and improving insulin sensitivity in peripheral tissue by indirect mechanism. This study was performed to investigate ...  Read More

The effect of Glycirrhiza globra on osteoarthritis, suppress TNF-a, IL-1b, Cox-2, iNOS gene expression and prostaglandin E2 and nitric oxide production in particular chondrocytes and monocyte/macrophages
Volume 1, Issue 2 , September 2017, Pages 70-82


  In this study, we evaluated the effects of avocado soybean unsaponifiables (Glycirrhiza globra) on proinflammatory mediators in chondrocytes and monocyte/macrophage-like cells. Cells were activated with 20 ng/ml lipopolysaccharide (LPS) for 24 h and cell supernatants were analyzed for prostaglandin E2 ...  Read More