In this study, effect of vitamin E on kidney after exposure to formaldehyde was evaluated. 24 adult male wistar rats divided randomly in three groups: control, formaldehyde (E1), vitamin E and formaldehyde (E2). After two weeks rats were sacrificed, and 5 ml of blood was taken from their heart. Blood urea nitrogen (BUN) and creatinine concentrations were measured. BUN concentration was significantly increased in E1 (P=0.03) and E2 groups (P=0.02) compare with control group. There were no significant differences in creatinine levels between groups (p=0.11). The results showed that vitamin E probably protect kidney against formaldehyde alterations in rat. It may be possible to use vitamin E when increasing blood urea concentrations to restore urea plasma balance and prevent kidney damage.