Traumatic Brain Injury (TBI) can occur when the head suddenly hits an object and the internal forces produce damage to the brain, disrupting its normal function, with or without structural changes. TBI causes disability and death to almost all age groups. This review aimed to describe the biomechanics that were involved in brain injury of varying severity degrees and summarizes the neurochemical and metabolic changes to predict the effect of brain injury. There are various methods in biomechanics measurements for TBI, as well as computational models to understand several pathophysiology and effects of TBI that are very important to find better TBI treatments. Moreover, several neurochemical and metabolic changes in brain may explain the short and long-term effect of TBI to the brain. The various methods in biomechanics measurements for TBI are very important to find better treatments.