Structural bioinformatics and computational methodologies facilitate antibodies design. The rational design is used to achieve a new function or adopt a new structure. Computer algorithms can systematically search amino acid sequences and select the best one. One of the important points of protein therapeutics is utilizing as drug. The present study reviewed recent studies about antibody design, antibody structure modeling, antibody prediction, and stability, pharmacokinetics and recent algorithms used in antibody design. By advanced technology with computational technologies development of therapeutics antibodies is possible. In early stages, several methods of predicting protein structure and de novo protein design were presented.