Immunodeficiency cases are a common cause of hospital deaths in hospitalized patients. Given the high prevalence of nosocomial deaths due to infection in immunocompromised patients, we aimed to evaluate Tuberculosis (TB), syphilis, hepatitis B and C, HIV and chickenpox in hospitalized immunocompromised patients, dialysis and Transplantation analysis of Shahid Sadoughi Hospital in 2017. This study was a descriptive cross-sectional study. The study population consisted of 100 patients with immunodeficiency admitted in chemotherapy, dialysis and transplantation wards of Yazd Shahid Sadoughi Hospital in 2017. Based on the obtained results, it could be concluded that HIV Ab, HCV Ab and HBS Ag tests are more prevalent in immunocompromised patients.