The combination effects of theophylline and corticosteroids in COVID-19

doi:10.22034/HBB.2020.13

Document Type : Hypothesis

10.22034/HBB.2020.13

Abstract

Late in 2019, the novel coronavirus disease (COVID-19) became pandemic. The disease has associated with severe inflammatory symptoms of the respiratory epithelial cells and the dysfunction of several organs of the body. Studies have shown that theophylline plays an important role in acute inflammation and has a synergistic effect on low therapeutic concentrations with corticosteroid drugs and amplifies anti-inflammatory effect of corticosteroids by activating histone deacetylase-2 (HDAC2), which decreases corticosteroid resistance by increasing the affinity of corticosteroid receptors to corticosteroid drugs. Therefore, theophylline could be considered as an adjunctive anti-inflammatory drug in combination with corticosteroids in the treatment of patients with COVID-19.

Keywords

References

[1]. Xu X, Chen P, Wang J, Feng J, Zhou H, Li X, Zhong W, Hao P: Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Sci China Life Sci, 2020, 63: 457-60.

[2]. Barnes PJ, Adcock I: Transcription factors and asthma. Eur Respir J, 1998, 12: 221-34.

[3]. Barnes PJ, Karin M: Nuclear factor pivotal transcription factor in chronic inflammatory diseases. N Engl J Med, 1997, 336: 1066-71.

[4]. Wright JG, Christman JW: The role of nuclear factor kappa B in the pathogenesis of pulmonary diseases: implications for therapy. Am J Respir, 2003, 2: 211-19.

[5]. Soler ZM, Patel ZM, Turner JH, Holbrook EH: A primer on viral‐associated olfactory loss in the era of COVID‐19. Int Forum Allergy Rhinol, Wiley Online Library; 2020.

[6]. Rabe KF: Global initiative for chronic obstructive lung disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. GOLD executive summary. Am J Respir Crit Care Med, 2007, 176: 532-55.

[7]. Rennard SI: Treatment of stable chronic obstructive pulmonary disease. Lancet, 2004, 364: 791-802.

[8]. Sutherland ER, Cherniack RM: Management of chronic obstructive pulmonary disease. N Engl J Med, 2004, 350: 2689-97.

[9]. Barnes PJ: Theophylline. Pharmaceuticals, 2010, 3: 725-47.

[10]. Barnes PJ: Theophylline in chronic obstructive pulmonary disease: new horizons. Proc Am Thorac Soc, 2005, 2: 334-39.

[11]. ZuWallack RL, Mahler DA, Reilly D, Church N, Emmett A, Rickard K, Knobil K: Salmeterol plus theophylline combination therapy in the treatment of COPD. Chest, 2001, 119: 1661-70.

[12]. Kirsten DK, Wegner RE, Jorres RA, Magnussen H: Effects of theophylline withdrawal in severe chronic obstructive pulmonary disease. Chest, 1993, 104: 1101-1107.

[13]. Barnes P: How corticosteroids control inflammation: Quintiles Prize Lecture 2005. Br J Pharmacol, 2006; 245–54.

[14]. Ito K, Ito M, Elliott WM, Cosio B, Caramori G, Kon OM, Barczyk A, Hayashi S, Adcock IM, Hogg JC: Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med, 2005, 352: 1967-76.

Health Biotechnology and Biopharma (HBB)

The combination effects of theophylline and corticosteroids in COVID-19

References

References

Volume 4, Issue 3
December 2020
Pages 1-5

The combination effects of theophylline and corticosteroids in COVID-19

References

References

Volume 4, Issue 3December 2020Pages 1-5

Volume 4, Issue 3
December 2020
Pages 1-5