Biological sciences
Mohammad Ali Pahlevan Neshan; Payam Shahnazi Gerdehsang; Ahmad Bereimipour; Nazila Bostanshirin; Haniyeh Sadat Hosseininia; Kaykhosro Moridi; Amin Ebrahimi Sadrabadi; Arsalan Jalili
Abstract
Chronic inflammation in colorectal cancer can result in the progression of tumorigenesis. Inflammation in the colorectal part of the body can be affected by microbiota, as well as an individual diet. These two factors play a critical role in cancer types related to the colon and rectum. This inflammation ...
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Chronic inflammation in colorectal cancer can result in the progression of tumorigenesis. Inflammation in the colorectal part of the body can be affected by microbiota, as well as an individual diet. These two factors play a critical role in cancer types related to the colon and rectum. This inflammation could lose the protective epithelial layer of colorectal cancerous cells and, thus, translocation of healthy flora to inner layers. Pathogenic bacteria can also cause inflammation induction and tumorigenesis in the intestines. A change in the bacteria composition and some bacteria metabolites can also play a role in colorectal cancer. Dysbiosis can be affected by an individual diet. In this paper, the importance of diet and microbiota content on inflammation has been reviewed, and finally, in silico investigation confirmed their interplay.
Pharmaceutical sciences
Neeraja Podichety; Sivakumar Ramaiah
Abstract
Oral and oropharyngeal cancers are a large group of cancers that fall under the category of cancer of the head and neck. Current therapy includes surgery and radiotherapy associated with extreme morbidity and a decline in the quality of life. At advanced stages, oral cancer is often diagnosed and has ...
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Oral and oropharyngeal cancers are a large group of cancers that fall under the category of cancer of the head and neck. Current therapy includes surgery and radiotherapy associated with extreme morbidity and a decline in the quality of life. At advanced stages, oral cancer is often diagnosed and has a poor prognosis. Hence, an attempt was made to understand current status, needs and developments in oral cancer. This review provided epidemiology, risk factors and methods of screening of oral cancer. It reviewed current treatment strategies and risks associated oral cancer treatment. This review focused on recent developments in oral cancer research. Therapeutic peptides of microbial origin have proven to be effective in oral cancer. Hence, microorganisms and their peptides are reviewed which may be considered as novel leads for the treatment of oral and oropharyngeal cancers.
Medicinal sciences
Jamshid Ayatollahi; Forouzan Desin; Mohammad Sharifyazdi; Seyed Alireza Mousavi; Zohre Akhondimeybodi; Faezehsadat Heidari; Samaneh Mazidi; Vahid Sharifi; Sadiah Dehghani; Alireza Etemadieh; Mahdie Hamidfar; Seyed Hossein shahcheraghi
Abstract
Various factors are effective in reduction or increase of Erythrocyte Sedimentation Rate (ESR). This study was designed to investigate the effective factors on ESR in adults participating study in Yazd in Iran. In this study, the data in cohort study was used. The variables of age, sex, Body Mass Index ...
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Various factors are effective in reduction or increase of Erythrocyte Sedimentation Rate (ESR). This study was designed to investigate the effective factors on ESR in adults participating study in Yazd in Iran. In this study, the data in cohort study was used. The variables of age, sex, Body Mass Index (BMI), alcohol consumption, smoking, infection, inflammation, cancer, and blood pressure were collected. There is a significant relationship between age, sex, systolic blood pressure, BMI, physical activity, joint and heart pain, osteoporosis and smoking history with ESR. Cancer history and diastolic blood pressure variables have no significant effect on ESR values. Results showed that ESR levels in an adult population are generally affected by age and sex.
Pharmaceutical sciences
Pravin D Badhe; Ashwini Badhe; Kajal Nadaf; Srushti Deshmukh; Kishor Otari
Abstract
As antioxidants prevent free radical caused DNA damage, they lower the risk of developing chronic diseases. The present study evaluated the impact of fatty acid-rich fractions of Andrographis Paniculata Nees (AP) on free radical-induced DNA damage. We prepared fatty acid-rich fractions with dried AP ...
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As antioxidants prevent free radical caused DNA damage, they lower the risk of developing chronic diseases. The present study evaluated the impact of fatty acid-rich fractions of Andrographis Paniculata Nees (AP) on free radical-induced DNA damage. We prepared fatty acid-rich fractions with dried AP plants and analyzed them qualitatively using gas chromatography. In order to determine their cytotoxicity and free radical scavenging activities, MTT and Viacount assays were performed. In vitro proliferation assay was performed to assess the cell proliferation after treating with hydrogen peroxide (H2O2) and Ultra Violet-C (UVC). Further testing of the fractions was carried out using a high alkaline comet assay (pH>13) to determine their DNA-protective capacity. Our results indicated that AP fractions containing fatty acids possess DNA protective ability against H2O2 and UVC rays in human dermal fibroblasts.
Biological sciences
Saeed Dorgaleleh; Zahra Toutounchi; Mahsa Soltani; Karim naghipoor; Morteza Oladnabi
Abstract
Ectodermal dysplasia (ED) is a genetic disorder which is characterized by deficient tissues from ectoderm and mesoderm. In this systematic review, two researchers searched keywords such as Ectodermal Dysplasia and Hypohidrotic Ectodermal Dysplasia (HED) in Medline (PubMed), Scopus, and Web of Science ...
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Ectodermal dysplasia (ED) is a genetic disorder which is characterized by deficient tissues from ectoderm and mesoderm. In this systematic review, two researchers searched keywords such as Ectodermal Dysplasia and Hypohidrotic Ectodermal Dysplasia (HED) in Medline (PubMed), Scopus, and Web of Science databases were searched until June 2020. In the first search 885 articles were found. After including and excluding criteria, included articles were reduced to 53 in Scopus, 11 in Web of Science, and 11 in PubMed. The point is that out of 75 selected studies, 52 articles were identified the cause of infection in ectodermal dysplasia as mutations in the NEMO gene and its subsets.
Biological sciences
Mehdi Ahmadifar; Mina Nikandish; Nika Mashhadizadeh; Mohammad Hossein Azhir; sadaf reihani; ghazal hakiminezhad
Abstract
Polycystic Ovary Syndrome (PCOS) is the most common heterogeneous Endocrine (EC) disorder in women of childbearing age, which has an increasing trend in the number of patients recently. Although women with PCOS have been shown to triple the risk of EC compared to women without polycystic ovary syndrome, ...
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Polycystic Ovary Syndrome (PCOS) is the most common heterogeneous Endocrine (EC) disorder in women of childbearing age, which has an increasing trend in the number of patients recently. Although women with PCOS have been shown to triple the risk of EC compared to women without polycystic ovary syndrome, there are precise molecular mechanisms that increase the risk of EC in women with ovarian syndrome. Therefore, clinical strategies to prevent EC in PCOS are not well known. Although, elevated estrogen levels and decreased apoptosis have been suggested as potential mechanisms, there is no clarity on how these and other factors interact to increase the risk of EC in polycystic ovary syndrome. In this article, we try to review the functional mechanisms of TUBB8, SOX9 and BCL2 genes to examine their effect on controlling or promoting the risk of EC.
