Design and computational analysis of a derivative of camptothecin
Volume 2, Issue 4 , March 2019, Pages 1-10

  Camptothecin (CPT) as anti-tumor quinoline alkaloid drug is demonstrated. In this research, a derivative of camptothecin, Diol camptothecin, was designed. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties were computed to achieve appreciate bioavailability and computational ...  Read More

Therapy, incidence and trend of head and neck malignancies in Yazd, Iran
Volume 2, Issue 4 , March 2019, Pages 11-21

  In this study, we investigated the incidence and trend of head and neck malignant tumors between 2004 and 2015 in Yazd, Iran. A database study was conducted using the tumor registry data which was taken from Shahid Sadoughi hospital in Yazd. This study consisted of 824 patients that 57.9 % were men and ...  Read More

Study on DNA conformational transition affected by extremely low frequency magnetic field
Volume 2, Issue 4 , March 2019, Pages 22-31

  Increased application of electrical devices and consequent expansion of electrical distribution network, expose us to extremely low frequency electromagnetic fields (ELF-EMF) more than ever. Mechanisms of action of ELF-EMFs on cells and biomolecules are not well understood. Presence of specific sequence ...  Read More

Expression profiling of matrix metalloproteinase in adipose-derived stem cells under simulated microgravity condition
Volume 2, Issue 4 , March 2019, Pages 32-39

  The extracellular matrix (ECM) provides the cellular environment required during development and morphogenesis. The mechanical forces could influence the expression of ECM components. Matrix metalloproteinase (MMP) is a family of proteolytic enzymes participated in ECM remodeling and degradation. We ...  Read More

Evaluation of common polymorphisms (GTSM1, GSTT1 and GSTP1) in S-glutathione transferase family and susceptibility to basal cell carcinoma (BCC) in Iranian population
Volume 2, Issue 4 , March 2019, Pages 40-55

  The glutathione S-transferase (GST) is a polymorphic supergene family of detoxification enzymes that are involved in the metabolism of potential carcinogens. To evaluate the association between polymorphisms in the GSTs (GSTT1, GSTM1 and GSTP1) and basal cell carcinoma (BCC), 50 BCC patients and 50 healthy ...  Read More

Optimized preparation of lysozyme loaded dextran-chitosan nanoparticles using D-optimal design
Volume 2, Issue 4 , March 2019, Pages 56-78

  In this study, optimized conditions were investigated using response surface methodology for the preparation of lysozyme loaded dextran-chitosan nanoparticles. Nanoparticles were prepared using polyelectrolyte complexation method. Relevant factors including polymer ratio, protein concentration, stirring ...  Read More