Abstract
The clinical studies proved the antimicrobial synergistic effect of probiotic bacteria and medicinal plants. In addition, this synergic effect can help to maintain food and prevent food corruption. There are plenty of pharmaceutical-probiotic products in the world and offering the same products in Iran ...
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The clinical studies proved the antimicrobial synergistic effect of probiotic bacteria and medicinal plants. In addition, this synergic effect can help to maintain food and prevent food corruption. There are plenty of pharmaceutical-probiotic products in the world and offering the same products in Iran is necessary. As Iran is the origin of variant medicinal plants that are used in Iranian conventional medicine, in this review, the synergistic effects of each one alone and with each other evaluated. The proposed mechanisms demonstrated that the oil essence part of plants and bacteriocins in probiotic bacteria, played the main synergistic role. Also, in this study, the synergistic effects of Iranian medicinal plants and probiotic bacteria assessed. It showed that some medicinal plants and probiotic bacteria would be able to have an adequate synergistic effect. Hence, using them in food and hygiene industries could reduce microbial contamination and improve society health.
Abstract
Hemiscorpius Lepturus is one of the most dangerous scorpion species in Iran. Four metalloproteinase inhibitors were detected in the transcriptome of venom gland of H.lepturus (HLMetInhibit1, HLMetInhibit2, HLMetInhibit3 and HLMetInhibit4). Their secondary and 3D structures were predicted using Iterative ...
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Hemiscorpius Lepturus is one of the most dangerous scorpion species in Iran. Four metalloproteinase inhibitors were detected in the transcriptome of venom gland of H.lepturus (HLMetInhibit1, HLMetInhibit2, HLMetInhibit3 and HLMetInhibit4). Their secondary and 3D structures were predicted using Iterative Threading Assembly Refinement (I-TASSER) server. Multiple alignments were performed by clustalW and phylogeny tree constructed using Maximum likelihood statistic method. Phylogeny results showed that, HLMetInhibit1 (MG764541) and HLMetInhibit4 (MG764544) had a different evolutionary pattern than HLMetInhibit2 (MG764542) and HLMetInhibit3 (MG764543). Molecular docking of metalloproteinase inhibitors against the human matrix metalloproteinase s (MMPs ) were performed using Hex V.8 software. Results showed that HLMetInhibit1 and HLMetInhibit4 had the strongest affinity against almost all human MMPs. The results showed using of the H.lepturus metalloproteinase inhibitor as novel human MMPs inhibitors. However, in silico finding should be tested in the future in vitro studies.
Abstract
Brain cancer is the second leading cause of death after leukemia for children. In this study, brain cancer cells (U-87MG) were cultured with 10 % FBS. The Macrovipera lebetina venom was purified by two methods of chromatography. Anti-adhesion and cytotoxic effects were investigated by trypan blue and ...
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Brain cancer is the second leading cause of death after leukemia for children. In this study, brain cancer cells (U-87MG) were cultured with 10 % FBS. The Macrovipera lebetina venom was purified by two methods of chromatography. Anti-adhesion and cytotoxic effects were investigated by trypan blue and MTT assay. Six fractions were obtained from gel filtration chromatography. Fraction N.5 had anti-adhesion and cytotoxic effects, it was selected for ion exchange chromatography. The effect of four fractions obtained from ion exchange chromatography on the brain cells and control cell was studied and fraction N.3 had the highest level of cytotoxicity. Anti-adhesion and fatal effects on the brain and control cells were estimated to be 26 and 14 %, respectively. In this study, the active fraction had a cytotoxic effect on the brain cancer cell line.
Abstract
Haemophilus influenzae causes various infectious diseases such as meningitis, septic arthritis, bacteriemia, ampyeme and cellulites. Although all subtypes of H. influenzae cause these infectious conditions, H. influenzae type b (Hib) is the most common subtype with a incidence of 95 % and it is known ...
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Haemophilus influenzae causes various infectious diseases such as meningitis, septic arthritis, bacteriemia, ampyeme and cellulites. Although all subtypes of H. influenzae cause these infectious conditions, H. influenzae type b (Hib) is the most common subtype with a incidence of 95 % and it is known to be a major cause of mortality and morbidity among children under 5 years of age in Asia. Hib vaccine is not entered in routine immunization program in children in Iran yet. The present results show that most Iranian infants that are not vaccinated with Hib-conjugate vaccines are susceptible to Hib diseases, which confirm the previous findings. We found that the protective titer of antibody against Hib is very low in children under 1 year old and gradually increases with age as it shown in other study. The decrease in the prevalence of Hib-associated disease in older children appears to be associated with age-related increases in anti- capsular polysaccharide (anti-CP) titers.
Abstract
The three major Genetically Modified (GM) foods such as soybeans, canola and corn have been introduced to the global market since 1990. In this article, the potential health impacts of genetically modified foods is reviewed. Contrary to the present biotechnological claims, transgenic products have not ...
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The three major Genetically Modified (GM) foods such as soybeans, canola and corn have been introduced to the global market since 1990. In this article, the potential health impacts of genetically modified foods is reviewed. Contrary to the present biotechnological claims, transgenic products have not proved to be harmless and in many in vivo studies have shown harmful effects. Many countries regulate the consumption of Genetically Modified Organisms (GMOs) at a specific percentage of the content and would require labelling the food packages containing GMOs. In some countries, total ban of plantation and consumption and importation of GMOs have been put in place. The acceptance and future use of GMOs by the people in many countries in the world is not guaranteed and discussions around its wide applications is in doubt.
Abstract
The aim of this study was to evaluate the effectiveness of acceptance and commitment group therapy on quality of life and physical symptoms in gastro-intestinal cancer patients. The research was quasi-experimental with pretest, posttest and control group. The statistical population included 32 men with ...
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The aim of this study was to evaluate the effectiveness of acceptance and commitment group therapy on quality of life and physical symptoms in gastro-intestinal cancer patients. The research was quasi-experimental with pretest, posttest and control group. The statistical population included 32 men with gastro-intestinal cancer. Subjects were selected by purposeful sampling and were randomly divided into two experimental (n = 16) and control groups. The experimental group received eight sessions of acceptance and commitment based group therapy and the control group was on the waiting list. Questionnaires used in this study were demographic information questionnaire, quality of life questionnaire for cancer patients and Powell and Enright physical symptoms questionnaire. The results showed that acceptance and commitment group therapy was able to improve the quality of life and physical symptoms.
