Drug repurposing against COVID-19 by GWAS
Volume 4, Issue 1 , June 2020, Pages 1-6


  This note is prepared by the authors of a recent publication on shared genetic architecture of drug response based on summary statistics from genome-wide association studies (GWAS) to propose a drug repurposing approach for the treatment of coronavirus COVID-19. The authors proposed that in silico studies ...  Read More

Specific signaling pathways and drugs play key role in regulation of angiogenesis
Volume 4, Issue 1 , June 2020, Pages 7-37


  In this study, angiogenesis inducers and inhibitors and some important drugs are introduced. Abnormal angiogenesis can occur if the balance between inhibitory and inducible factors disappears. Angiogenesis inducers include EGF, FGF2, TGF-β, VEGF, G-CSF, HGF, TGF-α, IL-8, TNF-α and angiogenesis ...  Read More

Antibiotic resistance pattern in Klebsiella pneumoniae strains isolated from children with urinary tract infections from Tabriz hospitals
Volume 4, Issue 1 , June 2020, Pages 38-45


  The aim of this study was to evaluate the resistance pattern and susceptibility of some antibiotics to K. pneumoniae isolated from urinary tract infections. In this descriptive cross-sectional study, 165 K. pneumoniae strains were collected from Tabriz hospitals during six months and were identified ...  Read More

Comparison of job burnout and general health in hospital staff with constant and rotating shifts
Volume 4, Issue 1 , June 2020, Pages 46-58


  In this study, causal-comparative research method was used. The study population was hospital staff of Bojnourd in North Khorasan in 2018 and General Health Questionnaire (GHQ) and Burnout Questionnaire were used for collecting data. The results showed that hospital staff were at greater risk of occupational ...  Read More

Investigating interaction between IL-17A, IL-17E, TNF-α and rs3783605 and its effect on VCAM-1 promoter activity in the human umbilical vein endothelial cells
Volume 4, Issue 1 , June 2020, Pages 59-67


  The present study is created to determine the effect of rs3783605 and its interaction with IL-17A, IL-17E and TNF-α cytokines on the action of VCAM-1 gene promoter in human umbilical vein endothelial cells (HUVEC). Recent research shows that IL-17A and TNF-α cytokines have main effect on ...  Read More

Insights into the evolutionary origin of Mycoplasma species
Volume 4, Issue 1 , June 2020, Pages 68-85


  Mycoplasma species are cell wall deficient intracellular microorganisms that are related to respiratory and urogenital infections in human being. In this study, we are providing insights into the Mycoplasma evolutionary origin based on the taxonomical characterization of such microorganism and also searching ...  Read More