The combination effects of theophylline and corticosteroids in COVID-19
Volume 4, Issue 3 , December 2020, Pages 1-5

  Late in 2019, the novel coronavirus disease (COVID-19) became pandemic. The disease has associated with severe inflammatory symptoms of the respiratory epithelial cells and the dysfunction of several organs of the body. Studies have shown that theophylline plays an important role in acute inflammation ...  Read More

Investigation of chemical components and antibacterial activity of yarrow (Achillea wilhelmsii) extract
Volume 4, Issue 3 , December 2020, Pages 6-18

  Herbal medicine is one of the oldest human approaches to treating diseases and yarrow (Achillea wilhelmsii) one of the most famous medicinal plants. Yarrow essential oil has anti-inflammatory, anti-spasm, anti-scalp, hair growth stimulation and topical skin healing due to chamazulene, cineole and borneol. ...  Read More

Quantitative evaluation of DYT1 promoter methylation in dystonia patients
Volume 4, Issue 3 , December 2020, Pages 19-27

  This study aimed at assessing the methylation state of the DYT1 gene in the pathogenesis of dystonia disease and evaluated the clinical feature. Thirty patients with no mutation in DYT1 gene and 30 normal individuals were investigated. The methylation of promoter in DYT1 gene was investigated using Real-time ...  Read More

Effect of spices and aromatic compounds on inhibit COVID_19 Mpro by docking analysis
Volume 4, Issue 3 , December 2020, Pages 28-46

  Coronavirus 2019 is a disaster in the 21st century and the lack of specific medications for prevention or treatment is a major need. In this regard, we conducted a conventional study to identify the main targets of coronavirus among spices compound. For this bioinformatics study, the ingredients structure ...  Read More

Prevalence and risk factors associated with Brucella abortus and Brucella melitensis human infections in Sistan va Baluchistan province, southwest of Iran
Volume 4, Issue 3 , December 2020, Pages 47-55

  Brucella spp., causes zoonotic infections. Our objective was screening and risk factors of Brucella species among human sera samples in Sistan va Baluchistan province of Iran. Fifty three sera samples were positive using indirect Enzyme Linked Immunosorbent Assay (ELISA), but the Wright and 2-ME agglutination ...  Read More

Tracking of intraperitoneally and direct intrahepatic administered mesenchymal stem cells expressing miR-146a-5p in mice hepatic tissue
Volume 4, Issue 3 , December 2020, Pages 56-76

  Given the functional drawbacks in the efficacy and safety of conventional miRNA delivery approaches, we aimed to assess the fate of mesenchymal stem cells (MSCs) expressing miR-146a-5p into the mice hepatic tissue. MSCs were xeno-transplanted through direct intrahepatic and intraperitoneal routes into ...  Read More