Document Type : Original Research Article

Authors

1 Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, ‎Tehran, Iran

2 Pasteur Institute of Iran

10.22034/hbb.2024.453663.1157

Abstract

Background: The survival rate for triple-negative breast cancer with metastasis is generally lower than other types of breast cancer. Finding specific molecular markers for timely determination of lymph node metastasis is of great importance.

Methods: We investigated the transcriptome profiles of two main subtypes of TNBC, i.e., BL1 and MSL on GEO database. Differentially expressed genes were checked for their association with clinical breast cancer on the UALCAN and bc-GenExMiner databases.

Results: GEO2R analysis revealed 1144 DEGs which were enriched to 25 genes attributed to lymphatic metastasis by MOET analysis. Further assessment of these genes on UALCAN showed that the expression of CAV1, VEGFC and, TIMP1 were significantly changed in TNBC-BL1 vs. TNBC-MSL subtypes.

Conclusion: Down-regulation of CAV1 gene was related to tumor formation and invasion in breast cancer cell lines as well as clinical cohort datasets.

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