Document Type : Hypothesis

Authors

• Mohadeseh Nemati ¹
• Fahima Danesh Pouya ¹
• Fateme Zarein ²
• Mahdieh Nemati ³
• Yousef Rasmi ¹
• Jafar Rezaie ⁴
• Tooba Hallaj ⁵

¹ Department of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

² Department of nanobiotechnology, Faculty of biological sciences, Tarbiat modares university, Tehran, Iran

³ Department of Medical Nanotechnology, Faculty of Advanced Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

⁴ Solid Tumor Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran

⁵ Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran

Abstract

Cancer cells are metabolically different from normal cells, including the Warburg effect and uses glutamine to fill the Tricarboxylic Acid (TCA) cycle. It was demonstrated inhibiting glutamine metabolism prevents tumor growth. The mammalian Target of Rapamycin (mTOR) is one of the signaling pathways that involve glutamine metabolism in cancer. Carbon Quantum dots (CQ-dots) nanoparticles are associated with the mTOR signaling pathway. These findings indicate that irregular glutamine metabolism are related to the growth of Colorectal Cancer (CRC). Thus, the activating glutamine metabolism via the mTOR pathway in CQ-dots treatments has toxic effect on CRC therapy. So, more investigations need for therapeutic application of these nanocarriers.

Keywords

• Colorectal cancer
• mTOR
• glutamine
• carbon quantum dots
• metabolism