Document Type : Hypothesis

Authors

1 Department of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

2 Department of nanobiotechnology, Faculty of biological sciences, Tarbiat modares university, Tehran, Iran

3 Department of Medical Nanotechnology, Faculty of Advanced Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

4 Solid Tumor Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran

5 Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran

10.22034/hbb.2022.335900.1027

Abstract

Cancer cells are metabolically different from normal cells, including the Warburg effect and uses glutamine to fill the tricarboxylic acid (TCA) cycle. It was demonstrated inhibiting glutamine metabolism prevents tumor growth. The mammalian target of rapamycin (mTOR) is one of the signaling pathways that involve glutamine metabolism in cancer. On the other hand, the carbon quantum dots (CQ-dots) nanoparticles can be used in cancer detection and treatment. These nanoparticles are associated with the mTOR signaling pathway too. The findings indicate that irregular glutamine metabolism is related to the growth of colorectal cancer (CRC). Thus, the activating glutamine metabolism via the mTOR pathway in CQ-dots treatments has toxic effect on CRC therapy. So, more investigations are needed for the therapeutic application of these nanocarriers as drug delivery systems.

Keywords