The aim of this study was to investigate the most common symptoms of COVID-19 patients in Yazd. This study was done during 2020-2021. All patients with positive PCR test were entered to this study. Finally, data was analyzed by SPSS software. The most common symptoms of COVID-19 patients were shortness of breath, fever and cough. There was a significant relationship between diabetes, lethargy, myalgia, chills, fever and loss of taste. Several symptoms including weakness, lethargy, dry cough, decreased appetite, were significantly more in the autumn season. According to the findings, the symptoms could have different prevalence in patients with underlying disease.