The three major Genetically Modified (GM) foods such as soybeans, canola and corn have been introduced to the global market since 1990. In this article, the potential health impacts of genetically modified foods is reviewed. Contrary to the present biotechnological claims, transgenic products have not proved to be harmless and in many in vivo studies have shown harmful effects. Many countries regulate the consumption of Genetically Modified Organisms (GMOs) at a specific percentage of the content and would require labelling the food packages containing GMOs. In some countries, total ban of plantation and consumption and importation of GMOs have been put in place. The acceptance and future use of GMOs by the people in many countries in the world is not guaranteed and discussions around its wide applications is in doubt.