Typhoid fever diseases menace the human health worldwide. This study assessed the prevalence of typhoid fever among children in Hilla City. A total of 217 samples were collected. Children were diagnosed with payrexia caused by S. typhi by records of medical used for statistical study tools considered. Most of patients aged 1-4 years and were male (54.4 %). Interestingly, our findings unraveled an increasing trend between 2014 and 2015, decresing during 2015-2016 but a sharp increase during 2016-2018. Puplic health interventions need to be under consideration to hinder the spread of infection. Studies of healthcare and proper pharmacotherapies would help to develop better control systems and comparison between urban and rural areas of infection.