The aim of the present study was to compare mental performance and hardiness of rural university students with urban university students in Shahid Chamran University of Ahwaz. This study had causal-comparative design. Samples were chosen randomly from 159 students (88 urban students and 71 rural students). Data were obtained from General Health Questionnaire (GHQ) and Psychological Hardiness Inventory (AHI). SPSS16 software was used to analyze the data. Descriptive and inferential analysis (t-test for independent groups) was conducted. Findings showed that there was no significant difference in two major variables (GHQ and AHI) between urban and rural students. The results of this study indicate that the people place of residence affect the severity of depression and somatic symptoms in rural and urban students.