Spirulina is a multicellular and filamentous blue-green microalgae. Its contains large amounts of protein (70 % dry weight), carotenoid (4000 mg/kg),omega-3 and omega-6 polyunsaturated fatty acids, Gamma Linoleic Acid (GLA), sulfolipids, glycolipids, polysaccharides, provitamins; vitamin A, vitamin E, vitamins B, mineral such as magnesium, iron, calcium, manganese, potassium, selenium and zinc. Due to its cost-effective and high nutritional value, it has used as protein-rich food and animal feed for improving meat production. This product commercially produced in large outdoor pools under controlled conditions. This microalga has soft cell walls that easily digested. New experimental supports the immunomodulation and antiviral effects of Spirulina. After that, it is used for astronauts on space missions. Although Spirulina might symbolize a functional food with potential helpful effects on human health. Therefore, the effect of food containing should evaluate in the future.