The aim of this study was to evaluate the resistance pattern and susceptibility of some antibiotics to K. pneumoniae isolated from urinary tract infections. In this descriptive cross-sectional study, 165 K. pneumoniae strains were collected from Tabriz hospitals during six months and were identified by standard laboratory tests in a dedicated environment. Antibiotic resistance assay was performed by disk diffusion method. The highest resistance of K. pneumoniae isolates to tetracycline antibiotics (71.5 %), ciprofloxacin (56.9 %) and ceftriaxone (41.8 %) and the highest sensitivity to gentamicin (87.9 %), imipenem (85.5 %) and Cefepime (81.8 %) obtained. With increasing prevalence of antibiotic resistance, early detection of antibiotic resistant strain is necessary to select appropriate treatment and prevent spread of antibiotic resistance.