Document Type : Original Research Article



The mucoadhesive microballons were prepared by using combination of polymer-polymer complexation (PAA-PVP) using solvent diffusion method. Mucoadhesive microballons is one of dosage forms which make available the prospectto increase the bioavailability of drug. The prepared delivery system managing the discharge rate of nizatidine between therapeutic absorption by extended the gastric emptying time. The delivery systems make certain accessibility of drug content at the assimilation site for the preferred period of time, also the possibility of enhancing the bioavailability and control the release of nizatidine show evidence of absorption by prolonging the gastric emptying time of the dosage form.