Document Type : Original Research Article



Coronavirus 2019 is a disaster in the 21st century and the lack of specific medications for prevention or treatment is a major need. In this regard, we conducted a conventional study to identify the main targets of coronavirus among spices compound. For this bioinformatics study, the ingredients structure was obtained from the PubChem database and the protease enzyme structure COVID_19 from the PDB database then molecular docking was performed by Molegro Virtual Docker (MVD) software. Based on the results, it could be concluded that the spices compounds interfere with the important amino acids in the enzymatic cavity to inhibit the protease enzyme virus. Regarding the binding energy among these compounds, the metabolites of curcuma longa, capsicum, zingiber has the strongest binding and inhibitory effect on the protease enzyme COVID_19. Therefore, these spices could be prescribed as a complementary treatment for patients with coronavirus infection in their food, but this study requires clinical investigation.


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